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CAS 571188-59-5
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
Codes：PALB-007、RIBO-009
Application context (from source-drug indications)
乳腺癌哌柏西利乳腺癌琥珀酸瑞波西利
Source drugs (routes using this intermediate)
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
tert-butyl piperazine-1-carboxylate→tert-butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate→5-bromo-2,4-dichloropyrimidine→cyclopentanamine→5-bromo-2-chloro-N-cyclopentylpyrimidin-4-amine→(E)-but-2-enoic acid→2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one→6-bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one→tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate→tert-butyl 4-(6-((6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate→1-(vinyloxy)butane→tert-butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate→5-bromo-2-nitropyridine
cyclopentanamine→tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate→tert-butyl 4-(6-((6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate→ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate→ethyl 4-(cyclopentylamino)-2-(methylthio)pyrimidine-5-carboxylate→(4-(cyclopentylamino)-2-(methylthio)pyrimidin-5-yl)methanol→4-(cyclopentylamino)-2-(methylthio)pyrimidine-5-carbaldehyde→1-(4-(cyclopentylamino)-2-(methylthio)pyrimidin-5-yl)ethanol→1-(4-(cyclopentylamino)-2-(methylthio)pyrimidin-5-yl)ethan-1-one→ethyl 2-(diethoxyphosphoryl)acetate→8-cyclopentyl-5-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one→6-bromo-8-cyclopentyl-5-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one→2-((4-nitrophenyl)sulfonyl)-3-phenyl-1,2-oxaziridine→6-bromo-8-cyclopentyl-5-methyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one→tributyl(1-ethoxyvinyl)stannane→tert-butyl 4-(6-((8-cyclopentyl-6-(1-ethoxyvinyl)-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate
cyclopentanamine→tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate→ethyl 3-oxobutanoate→N-cyclopentyl-3-oxo-N-(3-oxobutanoyl)butanamide→3-acetyl-1-cyclopentyl-6-hydroxy-4-methylpyridin-2(1H)-one→5-acetyl-2-chloro-1-cyclopentyl-4-methyl-6-oxo-1,6-dihydropyridine-3-carbaldehyde→tert-butyl 4-(6-guanidinopyridin-3-yl)piperazine-1-carboxylate sulfate→methyl carbamimidothioate sulfate
cyclopentanamine→tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate→2,4-dichloropyrimidine-5-carbonitrile→1-(2,4-dichloropyrimidin-5-yl)ethanone→2,4-dichloro-5-(2-methyl-1,3-dioxolan-2-yl)pyrimidine→1-(2-chloro-4-(cyclopentylamino)pyrimidin-5-yl)ethanone→4-methyleneoxetan-2-one→N-(5-acetyl-2-chloropyrimidin-4-yl)-N-cyclopentyl-3-oxobutanamide→6-acetyl-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one→2-chloro-8-cyclopentyl-5-methyl-6-(2-methyl-1,3-dioxolan-2-yl)pyrido[2,3-d]pyrimidin-7(8H)-one→tert-butyl 4-(6-((8-cyclopentyl-5-methyl-6-(2-methyl-1,3-dioxolan-2-yl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate→5-bromo-2-nitropyridine→tert-butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate→piperazine→1-(6-nitropyridin-3-yl)piperazine→PALB-044→(Z)-tert-butyl 4-(6-(2,3-bis(tert-butoxycarbonyl)guanidino)pyridin-3-yl)piperazine-1-carboxylate→1-(5-(piperazin-1-yl)pyridin-2-yl)guanidine hydrochloride→(E)-methyl 2-acetylbut-2-enoate→6-acetyl-4-amino-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-one→6-acetyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-one→chlorocyclopentane→6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-one→methyl 3-oxobutanoate
5-bromo-2,4-dichloropyrimidine→cyclopentanamine→5-bromo-2-chloro-N-cyclopentylpyrimidin-4-amine→prop-2-yn-1-ol→3-(2-chloro-4-(cyclopentylamino)pyrimidin-5-yl)prop-2-yn-1-ol→(2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methanol→dimethylamine→2-chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide→tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate→tert-butyl 4-(6-((7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate→5-chloro-2-nitropyridine→piperazine→1-(6-nitropyridin-3-yl)piperazine→tert-butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate
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