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CAS 577969-73-4
(4aR,8aR)-tert-butyl 2,2-dimethyl-6,8a-dihydro-4H-[1,3]dioxino[5,4-b]pyridine-5(4aH)-carboxylate
Codes：MIGA-019
Application context (from source-drug indications)
法布里病米加司他盐酸盐
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 米加司他盐酸盐Migalastat Hydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
tert-butyl (R)-4-formyl-2,2-dimethyloxazolidine-3-carboxylate→(R)-tert-butyl 4-((R)-1-hydroxyallyl)-2,2-dimethyloxazolidine-3-carboxylate→tert-butyl ((4R,5R)-2,2-dimethyl-4-vinyl-1,3-dioxan-5-yl)carbamate→3-iodoprop-1-ene→tert-butyl allyl((4R,5R)-2,2-dimethyl-4-vinyl-1,3-dioxan-5-yl)carbamate→(4aR,8aR)-tert-butyl 2,2-dimethyl-6,8a-dihydro-4H-[1,3]dioxino[5,4-b]pyridine-5(4aH)-carboxylate→(5R,6R)-tert-butyl 5-hydroxy-6-(hydroxymethyl)-5,6-dihydropyridine-1(2H)-carboxylate→(4aR,6aR,7aR,7bS)-tert-butyl 2,2-dimethyltetrahydro-4H-[1,3]dioxino[5,4-b]oxireno[2,3-d]pyridine-5(4aH)-carboxylate
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