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CAS 59528-27-7

(4-iodophenyl)methanamine hydrochloride

Codes：IRBE-018

Application context (from source-drug indications)

高血压Atorvastatin Calcium Hydrate/Irbesartan高脂血症Atorvastatin Calcium Hydrate/Irbesartan高血压厄贝沙坦/三氯噻嗪

Source drugs (routes using this intermediate)

DrugTierExpiry
Atorvastatin Calcium Hydrate/IrbesartanAtorvastatin Calcium Hydrate/IrbesartanTier C — Watch / trade-
厄贝沙坦/三氯噻嗪Irbesartan/TrichlormethiazideTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Atorvastatin Calcium Hydrate/Irbesartan优化路线steps: 3total yield: 1.83 g
1-pentanamidocyclopentane-1-carboxylic acid→(4-iodophenyl)methanamine hydrochloride→N-(4-iodobenzyl)-1-pentanamidocyclopentane-1-carboxamide→2-butyl-3-(4-iodobenzyl)-1,3-diazaspiro[4.4]non-1-en-4-one→(2-(1H-tetrazol-5-yl)phenyl)boronic acid
厄贝沙坦/三氯噻嗪优化路线steps: 3total yield: 1.83 g
1-pentanamidocyclopentane-1-carboxylic acid→(4-iodophenyl)methanamine hydrochloride→N-(4-iodobenzyl)-1-pentanamidocyclopentane-1-carboxamide→2-butyl-3-(4-iodobenzyl)-1,3-diazaspiro[4.4]non-1-en-4-one→(2-(1H-tetrazol-5-yl)phenyl)boronic acid

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