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CAS 15026-80-9

1-pentanamidocyclopentane-1-carboxylic acid

Codes：IRBE-017

Application context (from source-drug indications)

高血压Atorvastatin Calcium Hydrate/Irbesartan高脂血症Atorvastatin Calcium Hydrate/Irbesartan高血压厄贝沙坦/三氯噻嗪

Source drugs (routes using this intermediate)

DrugTierExpiry
Atorvastatin Calcium Hydrate/IrbesartanAtorvastatin Calcium Hydrate/IrbesartanTier C — Watch / trade-
厄贝沙坦/三氯噻嗪Irbesartan/TrichlormethiazideTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Atorvastatin Calcium Hydrate/Irbesartan优化路线steps: 3total yield: 1.83 g
1-pentanamidocyclopentane-1-carboxylic acid→(4-iodophenyl)methanamine hydrochloride→N-(4-iodobenzyl)-1-pentanamidocyclopentane-1-carboxamide→2-butyl-3-(4-iodobenzyl)-1,3-diazaspiro[4.4]non-1-en-4-one→(2-(1H-tetrazol-5-yl)phenyl)boronic acid
Atorvastatin Calcium Hydrate/Irbesartan优化路线steps: 5total yield: /
4'-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile→1-pentanamidocyclopentane-1-carboxylic acid→pentanoyl chloride→cyclopentanone→1-aminocyclopentane-1-carbonitrile→1-aminocyclopentane-1-carboxylic acid hydrochloride→4'-(aminomethyl)-[1,1'-biphenyl]-2-carbonitrile
厄贝沙坦/三氯噻嗪优化路线steps: 3total yield: 1.83 g
1-pentanamidocyclopentane-1-carboxylic acid→(4-iodophenyl)methanamine hydrochloride→N-(4-iodobenzyl)-1-pentanamidocyclopentane-1-carboxamide→2-butyl-3-(4-iodobenzyl)-1,3-diazaspiro[4.4]non-1-en-4-one→(2-(1H-tetrazol-5-yl)phenyl)boronic acid
厄贝沙坦/三氯噻嗪优化路线steps: 5total yield: /
4'-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile→1-pentanamidocyclopentane-1-carboxylic acid→pentanoyl chloride→cyclopentanone→1-aminocyclopentane-1-carbonitrile→1-aminocyclopentane-1-carboxylic acid hydrochloride→4'-(aminomethyl)-[1,1'-biphenyl]-2-carbonitrile

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This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.