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CAS 60706-87-8
dimethyl (6S)-7-ethyl-9,10,12,13-tetrahydro-5H-6,9-methanopyrido[1',2':1,2]azepino[4,5-b]indole-5,6(6aH)-dicarboxylate
Codes：VINF-004
Application context (from source-drug indications)
泌尿系肿瘤酒石酸长春氟宁尿路上皮癌酒石酸长春氟宁乳腺癌酒石酸长春氟宁肺癌酒石酸长春氟宁胃癌酒石酸长春氟宁阴茎癌酒石酸长春氟宁
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 酒石酸长春氟宁Vinflunine Ditartrate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
methyl (6S)-7-ethyl-9,10,12,13-tetrahydro-5H-6,9-methanopyrido[1',2':1,2]azepino[4,5-b]indole-6(6aH)-carboxylate→dimethyl (6S)-7-ethyl-9,10,12,13-tetrahydro-5H-6,9-methanopyrido[1',2':1,2]azepino[4,5-b]indole-5,6(6aH)-dicarboxylate→dimethyl (6S)-7-ethyl-10-oxo-9,10,12,13-tetrahydro-5H-6,9-methanopyrido[1',2':1,2]azepino[4,5-b]indole-5,6(6aH)-dicarboxylate→dimethyl (6S)-7-(1-hydroxyethyl)-10-oxo-9,10,12,13-tetrahydro-5H-6,9-methanopyrido[1',2':1,2]azepino[4,5-b]indole-5,6(6aH)-dicarboxylate→dimethyl (6S)-7-acetyl-10-oxo-9,10,12,13-tetrahydro-5H-6,9-methanopyrido[1',2':1,2]azepino[4,5-b]indole-5,6(6aH)-dicarboxylate→dimethyl (6S)-7-(1,1-difluoroethyl)-10-oxo-9,10,12,13-tetrahydro-5H-6,9-methanopyrido[1',2':1,2]azepino[4,5-b]indole-5,6(6aH)-dicarboxylate→methyl (6S)-7-(1,1-difluoroethyl)-10-oxo-9,10,12,13-tetrahydro-5H-6,9-methanopyrido[1',2':1,2]azepino[4,5-b]indole-6(6aH)-carboxylate→methyl (6S)-7-(1,1-difluoroethyl)-9,10,12,13-tetrahydro-5H-6,9-methanopyrido[1',2':1,2]azepino[4,5-b]indole-6(6aH)-carboxylate
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