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CAS 611-71-2

(R)-2-hydroxy-2-phenylacetic acid

Codes：MIRA-008

Application context (from source-drug indications)

神经性膀胱功能障碍米拉贝隆膀胱过度活动症米拉贝隆

Source drugs (routes using this intermediate)

DrugTierExpiry
米拉贝隆MirabegronTier B — Position early2029

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

米拉贝隆工艺路线steps: 4total yield: 14.24 kg
2-(4-nitrophenyl)ethan-1-amine hydrochloride→2-(2-aminothiazol-4-yl)acetic acid→(R)-2-hydroxy-2-phenylacetic acid→(R)-2-hydroxy-N-(4-nitrophenethyl)-2-phenylacetamide→(R)-2-((4-nitrophenethyl)amino)-1-phenylethan-1-ol hydrochloride→(R)-2-((4-aminophenethyl)amino)-1-phenylethan-1-ol hydrochloride
米拉贝隆优化路线steps: 4total yield: 89.1 g
2-(4-nitrophenyl)ethan-1-amine hydrochloride→2-(2-aminothiazol-4-yl)acetic acid→(R)-2-hydroxy-2-phenylacetic acid→(R)-2-hydroxy-N-(4-nitrophenethyl)-2-phenylacetamide→(R)-2-((4-nitrophenethyl)amino)-1-phenylethan-1-ol hydrochloride→(R)-2-((4-aminophenethyl)amino)-1-phenylethan-1-ol hydrochloride

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