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米拉贝隆
Tier B — Position earlyMirabegron · all drugs expiring in 2029 →
安斯泰来制药集团
Originator
2011
First approval
2029
Expiry (public)
$1.54B ▲
Peak sales
化学药
Type
Targets：ADRB3
Brand：Myrbetriq、Betanis/Betmiga/Myrbetriq、贝坦利、Betmiga、Betanis
Indications (approved)：神经性膀胱功能障碍、膀胱过度活动症
Regional status
US
批准上市
2012-06-28
EU
批准上市
2012-12-20
China
批准上市
2017-09-29
Japan
批准上市
2011-07-01
Synthetic routes & intermediates7 routes
Originator routes × 1Optimised (non-patent) × 5Process routes × 1
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OriginatorRoute 1Steps 5 · Total yield 310mg
| Code | CAS No. | Intermediate |
|---|---|---|
| MIRA-001 | 20780-53-4 | (R)-2-phenyloxirane |
| MIRA-002 | 29968-78-3 | 2-(4-nitrophenyl)ethan-1-amine hydrochloride |
| MIRA-003 | 223673-34-5 | (R)-2-((4-nitrophenethyl)amino)-1-phenylethan-1-ol |
| MIRA-004 | 223673-35-6 | tert-butyl (R)-(2-hydroxy-2-phenylethyl)(4-nitrophenethyl)carbamate |
| MIRA-005 | 223673-36-7 | tert-butyl (R)-(4-aminophenethyl)(2-hydroxy-2-phenylethyl)carbamate |
| MIRA-006 | 29676-71-9 | 2-(2-aminothiazol-4-yl)acetic acid |
| MIRA-007 | 1329485-55-3 | tert-butyl (R)-(4-(2-(2-aminothiazol-4-yl)acetamido)phenethyl)(2-hydroxy-2-phenylethyl)carbamate |
OptimisedRoute 3Steps 4 · Total yield 89.1 g
| Code | CAS No. | Intermediate |
|---|---|---|
| MIRA-002 | 29968-78-3 | 2-(4-nitrophenyl)ethan-1-amine hydrochloride |
| MIRA-006 | 29676-71-9 | 2-(2-aminothiazol-4-yl)acetic acid |
| MIRA-008 | 611-71-2 | (R)-2-hydroxy-2-phenylacetic acid |
| MIRA-009 | 521284-19-5 | (R)-2-hydroxy-N-(4-nitrophenethyl)-2-phenylacetamide |
| MIRA-010 | 521284-21-9 | (R)-2-((4-nitrophenethyl)amino)-1-phenylethan-1-ol hydrochloride |
| MIRA-011 | 521284-22-0 | (R)-2-((4-aminophenethyl)amino)-1-phenylethan-1-ol hydrochloride |
OptimisedRoute 4Steps 4 · Total yield 5 g
| Code | CAS No. | Intermediate |
|---|---|---|
| MIRA-001 | 20780-53-4 | (R)-2-phenyloxirane |
| MIRA-002 | 29968-78-3 | 2-(4-nitrophenyl)ethan-1-amine hydrochloride |
| MIRA-006 | 29676-71-9 | 2-(2-aminothiazol-4-yl)acetic acid |
| MIRA-012 | 100-52-7Available | benzaldehyde |
| MIRA-013 | 211635-75-5 | N-benzyl-2-(4-nitrophenyl)ethan-1-amine |
| MIRA-014 | 223673-46-9 | (R)-2-(benzyl(4-nitrophenethyl)amino)-1-phenylethan-1-ol |
| MIRA-015 | 391901-45-4 | (R)-2-((4-aminophenethyl)amino)-1-phenylethan-1-ol |
OptimisedRoute 5Steps 5 · Total yield 7.81 g
| Code | CAS No. | Intermediate |
|---|---|---|
| MIRA-006 | 29676-71-9 | 2-(2-aminothiazol-4-yl)acetic acid |
| MIRA-015 | 391901-45-4 | (R)-2-((4-aminophenethyl)amino)-1-phenylethan-1-ol |
| MIRA-016 | 104-10-9 | 2-(4-aminophenyl)ethanol |
| MIRA-017 | 104060-23-3 | tert-butyl (4-(2-hydroxyethyl)phenyl)carbamate |
| MIRA-018 | 695171-91-6 | tert-butyl (4-(2-oxoethyl)phenyl)carbamate |
| MIRA-019 | 2549-14-6 | (R)-2-amino-1-phenylethanol |
| MIRA-020 | - | tert-butyl (R)-(4-(2-((2-hydroxy-2-phenylethyl)amino)ethyl)phenyl)carbamate |
OptimisedRoute 6Steps 4 · Total yield 60 g
| Code | CAS No. | Intermediate |
|---|---|---|
| MIRA-019 | 2549-14-6 | (R)-2-amino-1-phenylethanol |
| MIRA-021 | 66659-20-9 | 2-(2-aminothiazol-4-yl)acetic acid hydrochloride |
| MIRA-022 | 89336-46-9 | 2-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)acetic acid |
| MIRA-023 | 211102-84-0 | 2-(2-(benzylamino)thiazol-4-yl)acetic acid |
| MIRA-024 | 887576-08-1 | 2-(2-((ethoxycarbonyl)amino)thiazol-4-yl)acetic acid |
| MIRA-025a | 26407-07-8 | 4-(2-bromoethyl)aniline hydrochloride |
| MIRA-025b | 52273-60-6 | 4-(2-chloroethyl)aniline hydrochloride |
| MIRA-026 | 1616489-60-1 | tert-butyl (4-(2-((4-(2-bromoethyl)phenyl)amino)-2-oxoethyl)thiazol-2-yl)carbamate |
| MIRA-027 | 1616489-61-2 | 2-(2-(benzylamino)thiazol-4-yl)-N-(4-(2-bromoethyl)phenyl)acetamide |
| MIRA-028 | - | ethyl (4-(2-((4-(2-chloroethyl)phenyl)amino)-2-oxoethyl)thiazol-2-yl)carbamate |
| MIRA-029 | 1616489-66-7 | tert-butyl (4-(2-((4-(2-chloroethyl)phenyl)amino)-2-oxoethyl)thiazol-2-yl)carbamate |
| MIRA-030 | - | tert-butyl (R)-(4-(2-((4-(2-((2-hydroxy-2-phenylethyl)amino)ethyl)phenyl)amino)-2-oxoethyl)thiazol-2-yl)carbamate |
| MIRA-031 | - | (R)-2-(2-(benzylamino)thiazol-4-yl)-N-(4-(2-((2-hydroxy-2-phenylethyl)amino)ethyl)phenyl)acetamide |
| MIRA-032 | - | ethyl (R)-(4-(2-((4-(2-((2-hydroxy-2-phenylethyl)amino)ethyl)phenyl)amino)-2-oxoethyl)thiazol-2-yl)carbamate |
OptimisedRoute 7Steps 5 · Total yield 18.7 g
| Code | CAS No. | Intermediate |
|---|---|---|
| MIRA-016 | 104-10-9 | 2-(4-aminophenyl)ethanol |
| MIRA-019 | 2549-14-6 | (R)-2-amino-1-phenylethanol |
| MIRA-021 | 66659-20-9 | 2-(2-aminothiazol-4-yl)acetic acid hydrochloride |
| MIRA-022 | 89336-46-9 | 2-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)acetic acid |
| MIRA-030 | - | tert-butyl (R)-(4-(2-((4-(2-((2-hydroxy-2-phenylethyl)amino)ethyl)phenyl)amino)-2-oxoethyl)thiazol-2-yl)carbamate |
| MIRA-033 | 381721-84-2 | 2-(2-(((benzyloxy)carbonyl)amino)thiazol-4-yl)acetic acid |
| MIRA-034 | 64220-26-4 | 2-(2-(tritylamino)thiazol-4-yl)acetic acid |
| MIRA-035 | 1447822-02-7 | tert-butyl (4-(2-((4-(2-hydroxyethyl)phenyl)amino)-2-oxoethyl)thiazol-2-yl)carbamate |
| MIRA-036 | 1447822-04-9 | benzyl (4-(2-((4-(2-hydroxyethyl)phenyl)amino)-2-oxoethyl)thiazol-2-yl)carbamate |
| MIRA-037 | 1447822-06-1 | N-(4-(2-hydroxyethyl)phenyl)-2-(2-(tritylamino)thiazol-4-yl)acetamide |
| MIRA-038 | 1447822-03-8 | tert-butyl (4-(2-oxo-2-((4-(2-oxoethyl)phenyl)amino)ethyl)thiazol-2-yl)carbamate |
| MIRA-039 | 1447822-05-0 | benzyl (4-(2-oxo-2-((4-(2-oxoethyl)phenyl)amino)ethyl)thiazol-2-yl)carbamate |
| MIRA-040 | 1447822-07-2 | N-(4-(2-oxoethyl)phenyl)-2-(2-(tritylamino)thiazol-4-yl)acetamide |
| MIRA-041 | - | benzyl (R)-(4-(2-((4-(2-((2-hydroxy-2-phenylethyl)amino)ethyl)phenyl)amino)-2-oxoethyl)thiazol-2-yl)carbamate |
| MIRA-042 | - | (R)-2-(2-((l1-phosphanyl)amino)thiazol-4-yl)-N-(4-(2-((2-hydroxy-2-phenylethyl)amino)ethyl)phenyl)acetamide |
ProcessRoute 2Steps 4 · Total yield 14.24 kg
| Code | CAS No. | Intermediate |
|---|---|---|
| MIRA-002 | 29968-78-3 | 2-(4-nitrophenyl)ethan-1-amine hydrochloride |
| MIRA-006 | 29676-71-9 | 2-(2-aminothiazol-4-yl)acetic acid |
| MIRA-008 | 611-71-2 | (R)-2-hydroxy-2-phenylacetic acid |
| MIRA-009 | 521284-19-5 | (R)-2-hydroxy-N-(4-nitrophenethyl)-2-phenylacetamide |
| MIRA-010 | 521284-21-9 | (R)-2-((4-nitrophenethyl)amino)-1-phenylethan-1-ol hydrochloride |
| MIRA-011 | 521284-22-0 | (R)-2-((4-aminophenethyl)amino)-1-phenylethan-1-ol hydrochloride |
Frequently asked questions
What are the approved indications of Mirabegron?
Approved indications include: 神经性膀胱功能障碍, 膀胱过度活动症.
When does the Mirabegron patent expire?
Based on public sources, the Mirabegron patent expires in 2029.
How many synthesis routes are recorded for Mirabegron?
7 synthesis routes are recorded; the shortest is 4 steps with 14.24 kg total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Mirabegron intermediates?
1 intermediate CAS of Mirabegron are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Mirabegron intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24