← Back to patent-cliff list
CAS 627-30-5
1-Chloro-3-hydroxypropane3-chloropropan-1-ol
Codes：(IX)169995-14-a、(III)169995-18-a、(III)169995-20-a、SILO-047
Application context (from source-drug indications)
避孕屈螺酮口腔炎，口疮屈螺酮经前焦虑性障碍屈螺酮经前期综合征屈螺酮痛经屈螺酮抑郁屈螺酮前列腺增生赛洛多辛下尿路症状赛洛多辛尿路结石症赛洛多辛肾结石赛洛多辛避孕行为赛洛多辛尿路结石赛洛多辛
Source drugs (routes using this intermediate)
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(1aR,1bR,3S,5aR,5bS,7aS,8aS,9aS,9bS,9cR,9dR)-1b,3-Dihydroxy-5a,7a-dimethylperhydrocyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthren-8-one→O-tert-Butyldimethylsilyl propargyl alcohol→(1aR,1bR,3S,5aR,5bS,7aS,8R,8aS,9aS,9bS,9cR,9dR)-8-[3-[tert-Butyl(dimethyl)silyloxy]-1-propynyl]-5a,7a-dimethylperhydrocyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthrene-1b,3,8-triol→(1aR,1bR,3S,5aR,5bS,7aS,8R,8aS,9aS,9bS,9cR,9dR)-8-[3-[tert-Butyl(dimethyl)silyloxy]propyl]-5a,7a-dimethylperhydrocyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthrene-1b,3,8-triol→(1aR,1bR,5aR,5bS,7aS,8R,8aS,9aS,9bS,9cR,9dR)-8-[3-[tert-Butyl(dimethyl)silyloxy]propyl]-1b,8-dihydroxy-5a,7a-dimethylperhydrocyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthren-3-one→(1aR,5aR,5bS,7aS,8R,8aS,9aS,9bS,9cR,9dR)-8-[3-[tert-Butyl(dimethyl)silyloxy]propyl]-8-hydroxy-5a,7a-dimethylperhydrocyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthren-3-one→(1aR,1bR,3S,5aR,5bS,7aS,8S,8aS,9aS,9bS,9cR,9dR)-8-(3-Hydroxypropyl)-5a,7a-dimethyloctadecahydro-1bH-cyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthrene-1b,3,8-triol→tert-Butyl(3-chloropropoxy)dimethylsilane→1-Chloro-3-hydroxypropane
(1aR,1bR,3S,5aR,5bS,7aS,8aS,9aS,9bS,9cR,9dR)-1b,3-Dihydroxy-5a,7a-dimethylperhydrocyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthren-8-one→2-(3-Chloropropoxy)oxane→1-Chloro-3-hydroxypropane→(1aR,1bR,3S,5aR,5bS,7aS,8S,9R,10aS,10bS,10cR)-5a,7a-Dimethyl-9-[3-(tetrahydro-2H-pyran-2-yloxy)propyl]hexadecahydrocyclopenta[a]cyclopropa[l]phenanthrene-1b,3,8(1H)-triol→2-(2-Bromoethyl)-1,3-dioxolane→(1aR,1bR,3S,5aR,5bS,7aS,8S,8aS,9aS,9bS,9cR,9dR)-8-[2-(1,3-Dioxolan-2-yl)ethyl]-5a,7a-dimethyloctadecahydro-1bH-cyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthrene-1b,3,8-triol
(1aR,1bR,3S,5aR,5bS,7aS,8aS,9aS,9bS,9cR,9dR)-1b,3-Dihydroxy-5a,7a-dimethylperhydrocyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthren-8-one→(3-Chloropropoxy)(trimethyl)silane→1-Chloro-3-hydroxypropane→(1aR,1bR,3S,5aR,5bS,7aS,8S,8aS,9aS,9bS,9cR,9dR)-5a,7a-Dimethyl-8-[3-[(trimethylsilyl)oxy]propyl]octadecahydro-1bH-cyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthrene-1b,3,8-triol→(1aR,1bR,3S,5aR,5bS,7aS,8S,8aS,9aS,9bS,9cR,9dR)-8-(3-Hydroxypropyl)-5a,7a-dimethyloctadecahydro-1bH-cyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthrene-1b,3,8-triol→(1R,2R,4R,5R,10R,11S,14S,15S,16S,18S,19S)-5-Hydroxy-10,14-dimethylspiro[hexacyclo[9.8.0.0(2,4).0(5,10).0(14,19).0(16,18)]nonadecane-15,2'-oxolane]-5',7-dione
indoline→nitroethane→2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl methanesulfonate→3-chloropropan-1-ol→((3-chloropropoxy)methyl)benzene→1-(3-(benzyloxy)propyl)indoline→1-(3-(benzyloxy)propyl)indoline-5-carbaldehyde→1-(3-(benzyloxy)propyl)-7-bromoindoline-5-carbaldehyde→1-(3-(benzyloxy)propyl)-5-formylindoline-7-carbonitrile→1-(3-(benzyloxy)propyl)-5-(2-nitropropyl)indoline-7-carbonitrile→1-(3-(benzyloxy)propyl)-5-(2-oxopropyl)indoline-7-carbonitrile→(R)-2-methylpropane-2-sulfinamide→(S)-N-(1-(1-(3-(benzyloxy)propyl)-7-cyanoindolin-5-yl)propan-2-yl)-2-methylpropane-2-sulfinamide→(R)-5-(2-aminopropyl)-1-(3-(benzyloxy)propyl)indoline-7-carbonitrile 2-hydroxy-2-phenylacetate→(R)-1-(3-(benzyloxy)propyl)-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carbonitrile→(R)-1-(3-(benzyloxy)propyl)-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carboxamide
Intermediates available on this site
No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.