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CAS 627-30-5
1-Chloro-3-hydroxypropane3-chloropropan-1-ol
登记编号：(IX)169995-14-a、(III)169995-18-a、(III)169995-20-a、SILO-047
应用背景（按来源药适应症）
避孕屈螺酮口腔炎，口疮屈螺酮经前焦虑性障碍屈螺酮经前期综合征屈螺酮痛经屈螺酮抑郁屈螺酮前列腺增生赛洛多辛下尿路症状赛洛多辛尿路结石症赛洛多辛肾结石赛洛多辛避孕行为赛洛多辛尿路结石赛洛多辛
来源药（使用该中间体的合成路线）
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(1aR,1bR,3S,5aR,5bS,7aS,8aS,9aS,9bS,9cR,9dR)-1b,3-Dihydroxy-5a,7a-dimethylperhydrocyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthren-8-one→O-tert-Butyldimethylsilyl propargyl alcohol→(1aR,1bR,3S,5aR,5bS,7aS,8R,8aS,9aS,9bS,9cR,9dR)-8-[3-[tert-Butyl(dimethyl)silyloxy]-1-propynyl]-5a,7a-dimethylperhydrocyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthrene-1b,3,8-triol→(1aR,1bR,3S,5aR,5bS,7aS,8R,8aS,9aS,9bS,9cR,9dR)-8-[3-[tert-Butyl(dimethyl)silyloxy]propyl]-5a,7a-dimethylperhydrocyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthrene-1b,3,8-triol→(1aR,1bR,5aR,5bS,7aS,8R,8aS,9aS,9bS,9cR,9dR)-8-[3-[tert-Butyl(dimethyl)silyloxy]propyl]-1b,8-dihydroxy-5a,7a-dimethylperhydrocyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthren-3-one→(1aR,5aR,5bS,7aS,8R,8aS,9aS,9bS,9cR,9dR)-8-[3-[tert-Butyl(dimethyl)silyloxy]propyl]-8-hydroxy-5a,7a-dimethylperhydrocyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthren-3-one→(1aR,1bR,3S,5aR,5bS,7aS,8S,8aS,9aS,9bS,9cR,9dR)-8-(3-Hydroxypropyl)-5a,7a-dimethyloctadecahydro-1bH-cyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthrene-1b,3,8-triol→tert-Butyl(3-chloropropoxy)dimethylsilane→1-Chloro-3-hydroxypropane
(1aR,1bR,3S,5aR,5bS,7aS,8aS,9aS,9bS,9cR,9dR)-1b,3-Dihydroxy-5a,7a-dimethylperhydrocyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthren-8-one→2-(3-Chloropropoxy)oxane→1-Chloro-3-hydroxypropane→(1aR,1bR,3S,5aR,5bS,7aS,8S,9R,10aS,10bS,10cR)-5a,7a-Dimethyl-9-[3-(tetrahydro-2H-pyran-2-yloxy)propyl]hexadecahydrocyclopenta[a]cyclopropa[l]phenanthrene-1b,3,8(1H)-triol→2-(2-Bromoethyl)-1,3-dioxolane→(1aR,1bR,3S,5aR,5bS,7aS,8S,8aS,9aS,9bS,9cR,9dR)-8-[2-(1,3-Dioxolan-2-yl)ethyl]-5a,7a-dimethyloctadecahydro-1bH-cyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthrene-1b,3,8-triol
(1aR,1bR,3S,5aR,5bS,7aS,8aS,9aS,9bS,9cR,9dR)-1b,3-Dihydroxy-5a,7a-dimethylperhydrocyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthren-8-one→(3-Chloropropoxy)(trimethyl)silane→1-Chloro-3-hydroxypropane→(1aR,1bR,3S,5aR,5bS,7aS,8S,8aS,9aS,9bS,9cR,9dR)-5a,7a-Dimethyl-8-[3-[(trimethylsilyl)oxy]propyl]octadecahydro-1bH-cyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthrene-1b,3,8-triol→(1aR,1bR,3S,5aR,5bS,7aS,8S,8aS,9aS,9bS,9cR,9dR)-8-(3-Hydroxypropyl)-5a,7a-dimethyloctadecahydro-1bH-cyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthrene-1b,3,8-triol→(1R,2R,4R,5R,10R,11S,14S,15S,16S,18S,19S)-5-Hydroxy-10,14-dimethylspiro[hexacyclo[9.8.0.0(2,4).0(5,10).0(14,19).0(16,18)]nonadecane-15,2'-oxolane]-5',7-dione
indoline→nitroethane→2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl methanesulfonate→3-chloropropan-1-ol→((3-chloropropoxy)methyl)benzene→1-(3-(benzyloxy)propyl)indoline→1-(3-(benzyloxy)propyl)indoline-5-carbaldehyde→1-(3-(benzyloxy)propyl)-7-bromoindoline-5-carbaldehyde→1-(3-(benzyloxy)propyl)-5-formylindoline-7-carbonitrile→1-(3-(benzyloxy)propyl)-5-(2-nitropropyl)indoline-7-carbonitrile→1-(3-(benzyloxy)propyl)-5-(2-oxopropyl)indoline-7-carbonitrile→(R)-2-methylpropane-2-sulfinamide→(S)-N-(1-(1-(3-(benzyloxy)propyl)-7-cyanoindolin-5-yl)propan-2-yl)-2-methylpropane-2-sulfinamide→(R)-5-(2-aminopropyl)-1-(3-(benzyloxy)propyl)indoline-7-carbonitrile 2-hydroxy-2-phenylacetate→(R)-1-(3-(benzyloxy)propyl)-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carbonitrile→(R)-1-(3-(benzyloxy)propyl)-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carboxamide
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