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CAS 63561-93-3
(16beta)-17-Hydroxy-16-methylpregna-4,9(11)-diene-3,20-dione
Codes：Betamethasone-005
Application context (from source-drug indications)
细菌感染和真菌感染倍他米松/克霉唑/硫酸庆大霉素
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 倍他米松/克霉唑/硫酸庆大霉素Betamethasone/Clotrimazole/Gentamicin Sulfate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
9-Hydroxyandrost-4-ene-3,17-dione→2-Hydroxy-2-methylpropanenitrile→(17alpha)-9,17-Dihydroxy-3-oxoandrost-4-ene-17-carbonitrile→(8S,9R,10S,13S,14S,17R)-9,17-Dihydroxy-10,13-dimethyl-1,2,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolane]-17-carbonitrile→(16beta)-17-Hydroxy-16-methylpregna-4,9(11)-diene-3,20-dione→(8S,10S,13S,14S)-10,13-Dimethyl-1,2,4,7,8,10,12,13,14,15-decahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolane]-17-carbonitrile→(4'aS,6'aS,6'bR,7'aR,8'aS,8'bS)-4'a,6'a-Dimethyl-3',4',4'a,6',6'a,7'a,8',8'a,8'b,9'-decahydrospiro[1,3-dioxolane-2,2'-naphtho[2',1':4,5]indeno[1,2-b]oxirene]-6'b(1'H)-carbonitrile→Methylmagnesium chloride→1-[(8S,10S,13S,14S,16S,17R)-17-Hydroxy-10,13,16-trimethyl-1,2,6,7,8,10,12,13,14,15,16,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-17-yl]ethan-1-one
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