CAS 75-86-5

2-hydroxy-2-methylpropanenitrile

Codes：ENZA-005、RALT-001

Application context (from source-drug indications)

激素敏感性前列腺肿瘤恩扎卢胺去势抵抗性前列腺肿瘤恩扎卢胺前列腺癌恩扎卢胺HIV感染拉替拉韦钾硬化性胆管炎拉替拉韦钾HTLV-Ⅰ感染拉替拉韦钾慢性肾功能不全拉替拉韦钾复发-缓解型多发性硬化拉替拉韦钾高甘油三酯血症拉替拉韦钾

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
恩扎卢胺Enzalutamide	Tier A — Act now	2027
拉替拉韦钾Raltegravir Potassium	Tier B — Position early	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

恩扎卢胺原研路线steps: 5total yield: 15 mg

2-fluoro-1-methyl-4-nitrobenzene→2-fluoro-4-nitrobenzoic acid→2-fluoro-N-methyl-4-nitrobenzamide→4-amino-2-fluoro-N-methylbenzamide→2-hydroxy-2-methylpropanenitrile→4-((2-cyanopropan-2-yl)amino)-2-fluoro-N-methylbenzamide→4-isothiocyanato-2-(trifluoromethyl)benzonitrile

拉替拉韦钾原研路线steps: 11total yield: 91.5 g

2-hydroxy-2-methylpropanenitrile→2-amino-2-methylpropanenitrile→benzyl (2-cyanopropan-2-yl)carbamate→benzyl (Z)-(1-amino-1-(hydroxyimino)-2-methylpropan-2-yl)carbamate→methyl 2-(2-(((benzyloxy)carbonyl)amino)propan-2-yl)-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylate→methyl 2-(2-(((benzyloxy)carbonyl)amino)propan-2-yl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylate→(4-fluorophenyl)methanamine→benzyl (2-(4-((4-fluorobenzyl)carbamoyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)propan-2-yl)carbamate→2-(2-aminopropan-2-yl)-N-(4-fluorobenzyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxamide→5-methyl-1,3,4-oxadiazole-2-carbonyl chloride→5-methyl-1H-tetrazole→ethyl 2-chloro-2-oxoacetate→potassium 5-methyl-1,3,4-oxadiazole-2-carboxylate

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