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CAS 637354-25-7
2-(methylsulfonyl)-4-(pyridin-3-yl)pyrimidine
Codes：FLUM-001
Application context (from source-drug indications)
慢性髓细胞白血病甲磺酸氟马替尼髓系白血病慢性期甲磺酸氟马替尼
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 甲磺酸氟马替尼Flumatinib Mesylate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-(methylsulfonyl)-4-(pyridin-3-yl)pyrimidine→2-methyl-5-nitropyridin-3-amine→N-(2-methyl-5-nitropyridin-3-yl)-4-(pyridin-3-yl)pyrimidin-2-amine→2-methyl-N3-(4-(pyridin-3-yl)pyrimidin-2-yl)pyridine-3,5-diamine→4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzoic acid→N-(6-methyl-5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)pyridin-3-yl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide
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