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CAS 68858-20-8
(((9H-fluoren-9-yl)methoxy)carbonyl)-L-valine
Codes：ROMI-043
Application context (from source-drug indications)
外周T细胞淋巴瘤罗米地辛淋巴瘤罗米地辛嗜铬细胞瘤罗米地辛皮肤T细胞淋巴瘤罗米地辛非霍奇金淋巴瘤罗米地辛黑色素瘤罗米地辛
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 罗米地辛Romidepsin | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
methyl N-(((9H-fluoren-9-yl)methoxy)carbonyl)-S-trityl-D-cysteinyl-L-threonyl-L-valinate→(3S,9S,12R,16S,Z)-6-ethylidene-3,12-diisopropyl-16-((E)-4-(tritylthio)but-1-en-1-yl)-9-((tritylthio)methyl)-1-oxa-4,7,10,13-tetraazacyclohexadecane-2,5,8,11,14-pentaone→ROMI-034→N-(((9H-fluoren-9-yl)methoxy)carbonyl)-S-trityl-D-cysteine→methyl N-(((9H-fluoren-9-yl)methoxy)carbonyl)-S-trityl-D-cysteinyl-L-threoninate→methyl (Z)-2-((S)-2-((R)-2-amino-3-methylbutanamido)-3-(tritylthio)propanamido)but-2-enoate→(5R,8S,Z)-11-ethylidene-1-(9H-fluoren-9-yl)-5-isopropyl-3,6,9-trioxo-8-((tritylthio)methyl)-2-oxa-4,7,10-triazadodecan-12-oic acid→ROMI-041→ROMI-042→(((9H-fluoren-9-yl)methoxy)carbonyl)-L-valine
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