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CAS 6928-85-4
4-Methylpiperazin-1-amine
Codes：Rifampicin-012
Application context (from source-drug indications)
结核分枝杆菌感染盐酸乙胺丁醇/利福平/异烟肼结核分枝杆菌感染利福平麻风分枝杆菌感染利福平肺结核利福平脑膜炎球菌性脑膜炎利福平新型冠状病毒感染利福平呼吸道病毒感染利福平
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Ethambutol Hydrochloride/Rifampicin/IsoniazidEthambutol Hydrochloride/Rifampicin/Isoniazid | Tier C — Watch / trade | - |
| RifampicinRifampicin | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-21-Acetoxy-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-1,11-dione→(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17-Trihydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23,27,29-tetraoxo-8,30-dioxa-24-azatetracyclo[23.3.1.1(4,7).0(5,28)]triaconta-1(28),2,4,9,19,21,25-heptaen-13-yl acetate→N,N-Dihydroxymethyl-t-butylamine→(10S,13E,15S,16R,17S,18R,19R,20R,21S,22S,23E,25Z)-17-(Acetyloxy)-3-tert-butyl-7,19,21-trihydroxy-15-methoxy-8,10,16,18,20,22,26-heptamethyl-11,27-dioxo-10,11-dihydro-2H-10,5-(epoxypentadeca[1,11,13]trienoimino)furo[2',3':7,8]naphtho[2,1-e][1,3]oxazin-3-ium-6-olate→Acetic acid (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-formyl-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl ester→4-Methylpiperazin-1-amine
(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17-Trihydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23,27,29-tetraoxo-8,30-dioxa-24-azatetracyclo[23.3.1.1(4,7).0(5,28)]triaconta-1(28),2,4,9,19,21,25-heptaen-13-yl acetate→N,N-Dihydroxymethyl-t-butylamine→2-Methylpropan-2-amine→(10S,13E,15S,16R,17S,18R,19R,20R,21S,22S,23E,25Z)-3-tert-Butyl-6,7,19,21-tetrahydroxy-15-methoxy-8,10,16,18,20,22,26-heptamethyl-11,27-dioxo-3,4,10,11-tetrahydro-2H-10,5-(epoxypentadeca[1,11,13]trienoimino)furo[2',3':7,8]naphtho[2,1-e][1,3]oxazin-17-yl acetate→(10S,13E,15S,16R,17S,18R,19R,20R,21S,22S,23E,25Z)-6,7,19,21-Tetrahydroxy-15-methoxy-3,8,10,16,18,20,22,26-octamethyl-11,27-dioxo-3,4,10,11-tetrahydro-2H-10,5-(epoxypentadeca[1,11,13]trienoimino)furo[2',3':7,8]naphtho[2,1-e][1,3]oxazin-17-yl acetate→(10S,13E,15S,16R,17S,18R,19R,20R,21S,22S,23E,25Z)-6,7,19,21-Tetrahydroxy-15-methoxy-8,10,16,18,20,22,26-heptamethyl-3-[2-(morpholin-4-yl)ethyl]-11,27-dioxo-3,4,10,11-tetrahydro-2H-10,5-(epoxypentadeca[1,11,13]trienoimino)furo[2',3':7,8]naphtho[2,1-e][1,3]oxazin-17-yl acetate→(10S,13E,15S,16R,17S,18R,19R,20R,21S,22S,23E,25Z)-3-(1-Ethylpiperidin-3-yl)-6,7,19,21-tetrahydroxy-15-methoxy-8,10,16,18,20,22,26-heptamethyl-11,27-dioxo-3,4,10,11-tetrahydro-2H-10,5-(epoxypentadeca[1,11,13]trienoimino)furo[2',3':7,8]naphtho[2,1-e][1,3]oxazin-17-yl acetate→4-Methylpiperazin-1-amine→N-Methylpiperazine
(2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-21-Acetoxy-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-1,11-dione→(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17-Trihydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23,27,29-tetraoxo-8,30-dioxa-24-azatetracyclo[23.3.1.1(4,7).0(5,28)]triaconta-1(28),2,4,9,19,21,25-heptaen-13-yl acetate→N,N-Dihydroxymethyl-t-butylamine→(10S,13E,15S,16R,17S,18R,19R,20R,21S,22S,23E,25Z)-17-(Acetyloxy)-3-tert-butyl-7,19,21-trihydroxy-15-methoxy-8,10,16,18,20,22,26-heptamethyl-11,27-dioxo-10,11-dihydro-2H-10,5-(epoxypentadeca[1,11,13]trienoimino)furo[2',3':7,8]naphtho[2,1-e][1,3]oxazin-3-ium-6-olate→Acetic acid (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-formyl-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl ester→4-Methylpiperazin-1-amine
(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17-Trihydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23,27,29-tetraoxo-8,30-dioxa-24-azatetracyclo[23.3.1.1(4,7).0(5,28)]triaconta-1(28),2,4,9,19,21,25-heptaen-13-yl acetate→N,N-Dihydroxymethyl-t-butylamine→2-Methylpropan-2-amine→(10S,13E,15S,16R,17S,18R,19R,20R,21S,22S,23E,25Z)-3-tert-Butyl-6,7,19,21-tetrahydroxy-15-methoxy-8,10,16,18,20,22,26-heptamethyl-11,27-dioxo-3,4,10,11-tetrahydro-2H-10,5-(epoxypentadeca[1,11,13]trienoimino)furo[2',3':7,8]naphtho[2,1-e][1,3]oxazin-17-yl acetate→(10S,13E,15S,16R,17S,18R,19R,20R,21S,22S,23E,25Z)-6,7,19,21-Tetrahydroxy-15-methoxy-3,8,10,16,18,20,22,26-octamethyl-11,27-dioxo-3,4,10,11-tetrahydro-2H-10,5-(epoxypentadeca[1,11,13]trienoimino)furo[2',3':7,8]naphtho[2,1-e][1,3]oxazin-17-yl acetate→(10S,13E,15S,16R,17S,18R,19R,20R,21S,22S,23E,25Z)-6,7,19,21-Tetrahydroxy-15-methoxy-8,10,16,18,20,22,26-heptamethyl-3-[2-(morpholin-4-yl)ethyl]-11,27-dioxo-3,4,10,11-tetrahydro-2H-10,5-(epoxypentadeca[1,11,13]trienoimino)furo[2',3':7,8]naphtho[2,1-e][1,3]oxazin-17-yl acetate→(10S,13E,15S,16R,17S,18R,19R,20R,21S,22S,23E,25Z)-3-(1-Ethylpiperidin-3-yl)-6,7,19,21-tetrahydroxy-15-methoxy-8,10,16,18,20,22,26-heptamethyl-11,27-dioxo-3,4,10,11-tetrahydro-2H-10,5-(epoxypentadeca[1,11,13]trienoimino)furo[2',3':7,8]naphtho[2,1-e][1,3]oxazin-17-yl acetate→4-Methylpiperazin-1-amine→N-Methylpiperazine
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