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Rifampicin
Tier C — Watch / tradeRifampicin
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Originator
1971
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：RNAP
Brand：Rifadin, Rimactane, Rifa, Rifadine, Rimactan, Rifamsolin
Indications (approved)：Mycobacterium tuberculosis infection, Mycobacterium leprae infection, Pulmonary tuberculosis, Meningococcal meningitis
Regional status
US
Approved
1971-05-21
EU
Phase III
2021-04-29
China
Approved
1981-01-01
Japan
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Factories producing this API3
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
3 producing factories on file — sign in to view the named list (factory details are not shown to guests).
Sign in to view factories →Synthetic routes & intermediates5 routes
Originator routes × 0Optimised (non-patent) × 5Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 4 · Total yield 572g([11C]rifampicin (FREE))
Rifampicin-001110-85-0Rifampicin-0025632-47-3Rifampicin-00330651-60-6Rifampicin-00413292-22-3Rifampicin-00554245-42-0Rifampicin-006145577-00-0Rifampicin-0071001315-05-4Rifampicin-008—API · Rifampicin
| Code | CAS No. | Intermediate |
|---|---|---|
| Rifampicin-001 | 110-85-0Available | Piperazine |
| Rifampicin-002 | 5632-47-3 | 1-Nitrosopiperazine |
| Rifampicin-003 | 30651-60-6 | 1-Aminopiperazine |
| Rifampicin-004 | 13292-22-3 | 3-Formylrifamycin |
| Rifampicin-005 | 54245-42-0 | Iodo[11C]methane |
| Rifampicin-006 | 145577-00-0 | Trifluoromethanesulfonic acid [11C]methyl ester |
| Rifampicin-007 | 1001315-05-4 | Acetic acid (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-8-(piperazin-1-yliminomethyl)-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl ester |
| Rifampicin-008 | - | 3-(4-[11C]Methylpiperazin-1-yliminomethyl)rifamycin |
OptimisedRoute 2Steps 4 · Total yield 9.5g(Rifampicin (FREE))
Rifampicin-0096998-60-3,14897-39-3Rifampicin-01013553-79-2Rifampicin-01155686-22-1Rifampicin-013—Rifampicin-00413292-22-3Rifampicin-0126928-85-4API · Rifampicin
| Code | CAS No. | Intermediate |
|---|---|---|
| Rifampicin-009 | 6998-60-3,14897-39-3 | (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-21-Acetoxy-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-1,11-dione |
| Rifampicin-010 | 13553-79-2 | (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17-Trihydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23,27,29-tetraoxo-8,30-dioxa-24-azatetracyclo[23.3.1.1(4,7).0(5,28)]triaconta-1(28),2,4,9,19,21,25-heptaen-13-yl acetate |
| Rifampicin-011 | 55686-22-1 | N,N-Dihydroxymethyl-t-butylamine |
| Rifampicin-013 | - | (10S,13E,15S,16R,17S,18R,19R,20R,21S,22S,23E,25Z)-17-(Acetyloxy)-3-tert-butyl-7,19,21-trihydroxy-15-methoxy-8,10,16,18,20,22,26-heptamethyl-11,27-dioxo-10,11-dihydro-2H-10,5-(epoxypentadeca[1,11,13]trienoimino)furo[2',3':7,8]naphtho[2,1-e][1,3]oxazin-3-ium-6-olate |
| Rifampicin-004 | 13292-22-3 | Acetic acid (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-formyl-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl ester |
| Rifampicin-012 | 6928-85-4 | 4-Methylpiperazin-1-amine |
OptimisedRoute 3Steps 2 · Total yield /
Rifampicin-01013553-79-2Rifampicin-00413292-22-3Rifampicin-01450-00-0Rifampicin-0154075-42-7Rifampicin-0164267-47-4Rifampicin-0174075-43-8Rifampicin-0186695-52-9Rifampicin-0194075-48-3Rifampicin-0204075-44-9Rifampicin-0214075-41-6Rifampicin-0224135-85-7API · Rifampicin
| Code | CAS No. | Intermediate |
|---|---|---|
| Rifampicin-010 | 13553-79-2 | (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17-Trihydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23,27,29-tetraoxo-8,30-dioxa-24-azatetracyclo[23.3.1.1(4,7).0(5,28)]triaconta-1(28),2,4,9,19,21,25-heptaen-13-yl acetate |
| Rifampicin-004 | 13292-22-3 | Acetic acid (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-formyl-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl ester |
| Rifampicin-014 | 50-00-0Available | Formaldehyde |
| Rifampicin-015 | 4075-42-7 | (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-5,6,9,17,19-Pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-8-[(pyrrolidin-1-yl)methyl]-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate |
| Rifampicin-016 | 4267-47-4 | (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-5,6,9,17,19-Pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-8-[(piperidin-1-yl)methyl]-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate |
| Rifampicin-017 | 4075-43-8 | (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-5,6,9,17,19-Pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-[(morpholin-4-yl)methyl]-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate |
| Rifampicin-018 | 6695-52-9 | 1-[[(2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-21-(Acetyloxy)-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-8-yl]methyl]piperidine-4-carboxylic acid |
| Rifampicin-019 | 4075-48-3 | (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-[(2,6-Dimethylpiperidin-1-yl)methyl]-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate |
| Rifampicin-020 | 4075-44-9 | (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-5,6,9,17,19-Pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-[(4-methylpiperazin-1-yl)methyl]-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate |
| Rifampicin-021 | 4075-41-6 | (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-[(Diethylamino)methyl]-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate |
| Rifampicin-022 | 4135-85-7 | (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-[(Dimethylamino)methyl]-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate |
OptimisedRoute 4Steps 4 · Total yield 14.02g(Rifampicin (FREE))
Rifampicin-01013553-79-2Rifampicin-01155686-22-1Rifampicin-02375-64-9Rifampicin-02494169-00-3Rifampicin-027—Rifampicin-025—Rifampicin-026—Rifampicin-0126928-85-4Rifampicin-028109-01-3API · Rifampicin
| Code | CAS No. | Intermediate |
|---|---|---|
| Rifampicin-010 | 13553-79-2 | (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17-Trihydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23,27,29-tetraoxo-8,30-dioxa-24-azatetracyclo[23.3.1.1(4,7).0(5,28)]triaconta-1(28),2,4,9,19,21,25-heptaen-13-yl acetate |
| Rifampicin-011 | 55686-22-1 | N,N-Dihydroxymethyl-t-butylamine |
| Rifampicin-023 | 75-64-9Available | 2-Methylpropan-2-amine |
| Rifampicin-024 | 94169-00-3 | (10S,13E,15S,16R,17S,18R,19R,20R,21S,22S,23E,25Z)-3-tert-Butyl-6,7,19,21-tetrahydroxy-15-methoxy-8,10,16,18,20,22,26-heptamethyl-11,27-dioxo-3,4,10,11-tetrahydro-2H-10,5-(epoxypentadeca[1,11,13]trienoimino)furo[2',3':7,8]naphtho[2,1-e][1,3]oxazin-17-yl acetate |
| Rifampicin-027 | - | (10S,13E,15S,16R,17S,18R,19R,20R,21S,22S,23E,25Z)-6,7,19,21-Tetrahydroxy-15-methoxy-3,8,10,16,18,20,22,26-octamethyl-11,27-dioxo-3,4,10,11-tetrahydro-2H-10,5-(epoxypentadeca[1,11,13]trienoimino)furo[2',3':7,8]naphtho[2,1-e][1,3]oxazin-17-yl acetate |
| Rifampicin-025 | - | (10S,13E,15S,16R,17S,18R,19R,20R,21S,22S,23E,25Z)-6,7,19,21-Tetrahydroxy-15-methoxy-8,10,16,18,20,22,26-heptamethyl-3-[2-(morpholin-4-yl)ethyl]-11,27-dioxo-3,4,10,11-tetrahydro-2H-10,5-(epoxypentadeca[1,11,13]trienoimino)furo[2',3':7,8]naphtho[2,1-e][1,3]oxazin-17-yl acetate |
| Rifampicin-026 | - | (10S,13E,15S,16R,17S,18R,19R,20R,21S,22S,23E,25Z)-3-(1-Ethylpiperidin-3-yl)-6,7,19,21-tetrahydroxy-15-methoxy-8,10,16,18,20,22,26-heptamethyl-11,27-dioxo-3,4,10,11-tetrahydro-2H-10,5-(epoxypentadeca[1,11,13]trienoimino)furo[2',3':7,8]naphtho[2,1-e][1,3]oxazin-17-yl acetate |
| Rifampicin-012 | 6928-85-4 | 4-Methylpiperazin-1-amine |
| Rifampicin-028 | 109-01-3Available | N-Methylpiperazine |
OptimisedRoute 5Steps 2 · Total yield /
Rifampicin-0296998-60-3,14897-39-3Rifampicin-01013553-79-2Rifampicin-03057375-25-4API · Rifampicin
| Code | CAS No. | Intermediate |
|---|---|---|
| Rifampicin-029 | 6998-60-3,14897-39-3 | (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-21-Acetoxy-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-1,11-dione |
| Rifampicin-010 | 13553-79-2 | (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17-Trihydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23,27,29-tetraoxo-8,30-dioxa-24-azatetracyclo[23.3.1.1(4,7).0(5,28)]triaconta-1(28),2,4,9,19,21,25-heptaen-13-yl acetate |
| Rifampicin-030 | 57375-25-4 | 3-Bromorifamycin S |
Frequently asked questions
What are the approved indications of Rifampicin?
Approved indications include: Mycobacterium tuberculosis infection, Mycobacterium leprae infection, Pulmonary tuberculosis, Meningococcal meningitis.
When does the Rifampicin patent expire?
No public expiry year is available for Rifampicin yet; this page updates once verified.
How many synthesis routes are recorded for Rifampicin?
5 synthesis routes are recorded; the shortest is 2 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Rifampicin intermediates?
4 intermediate CAS of Rifampicin are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Rifampicin intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-27