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CAS 749167-08-6
(S)-1-chloro-3-phenylpropan-2-amine
Codes：RITO-035
Application context (from source-drug indications)
慢性丙型肝炎帕利普韦/奥比他韦/利托那韦丙型肝炎帕利普韦/奥比他韦/利托那韦失代偿性肝硬化帕利普韦/奥比他韦/利托那韦肾功能不全帕利普韦/奥比他韦/利托那韦纤维化帕利普韦/奥比他韦/利托那韦终末期肾脏病帕利普韦/奥比他韦/利托那韦HIV感染乙醇达芦那韦/利托那韦
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 帕利普韦/奥比他韦/利托那韦Paritaprevir/Ombitasvir/Ritonavir | Tier C — Watch / trade | - |
| 乙醇达芦那韦/利托那韦Darunavir Ethanolate/Ritonavir | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
L-phenylalanine→tert-butyl ((2S,4S,5S)-5-amino-4-hydroxy-1,6-diphenylhexan-2-yl)carbamate succinate→(S)-2-amino-3-phenylpropan-1-ol→(S)-1-chloro-3-phenylpropan-2-amine→(S)-tert-butyl (1-chloro-3-phenylpropan-2-yl)carbamate→(S)-tert-butyl (1-cyano-3-phenylpropan-2-yl)carbamate→(S)-tert-butyl (1-oxo-3-phenylpropan-2-yl)carbamate→(2-nitroethyl)benzene→tert-butyl ((2S,4S,5S)-4-hydroxy-5-nitro-1,6-diphenylhexan-2-yl)carbamate→tert-butyl ((2S,4S,5S)-5-amino-4-hydroxy-1,6-diphenylhexan-2-yl)carbamate
L-phenylalanine→tert-butyl ((2S,4S,5S)-5-amino-4-hydroxy-1,6-diphenylhexan-2-yl)carbamate succinate→(S)-2-amino-3-phenylpropan-1-ol→(S)-1-chloro-3-phenylpropan-2-amine→(S)-tert-butyl (1-chloro-3-phenylpropan-2-yl)carbamate→(S)-tert-butyl (1-cyano-3-phenylpropan-2-yl)carbamate→(S)-tert-butyl (1-oxo-3-phenylpropan-2-yl)carbamate→(2-nitroethyl)benzene→tert-butyl ((2S,4S,5S)-4-hydroxy-5-nitro-1,6-diphenylhexan-2-yl)carbamate→tert-butyl ((2S,4S,5S)-5-amino-4-hydroxy-1,6-diphenylhexan-2-yl)carbamate
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