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CAS 72155-45-4
(S)-tert-butyl (1-oxo-3-phenylpropan-2-yl)carbamate
Codes：ATAZ-025、RITO-038
Application context (from source-drug indications)
HIV感染硫酸阿扎那韦/考比司他慢性丙型肝炎帕利普韦/奥比他韦/利托那韦丙型肝炎帕利普韦/奥比他韦/利托那韦失代偿性肝硬化帕利普韦/奥比他韦/利托那韦肾功能不全帕利普韦/奥比他韦/利托那韦纤维化帕利普韦/奥比他韦/利托那韦终末期肾脏病帕利普韦/奥比他韦/利托那韦HIV感染乙醇达芦那韦/利托那韦
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 硫酸阿扎那韦/考比司他Atazanavir Sulfate/Cobicistat | Tier C — Watch / trade | - |
| 帕利普韦/奥比他韦/利托那韦Paritaprevir/Ombitasvir/Ritonavir | Tier C — Watch / trade | - |
| 乙醇达芦那韦/利托那韦Darunavir Ethanolate/Ritonavir | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
tert-butyl hydrazinecarboxylate→tert-butyl 2-((2S,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazine-1-carboxylate→methyl 4-cyanobenzoate→methyl 4-(pyridin-2-yl)benzoate→4-(pyridin-2-yl)benzoic acid→(isobutyl carbonic) 4-(pyridin-2-yl)benzoic anhydride→(S)-tert-butyl (1-oxo-3-phenylpropan-2-yl)carbamate→(1R,2S)-2-((tert-butoxycarbonyl)amino)-1-cyano-3-phenylpropyl 4-(pyridin-2-yl)benzoate→tert-butyl (E)-2-((2R,3S)-3-((tert-butoxycarbonyl)amino)-4-phenyl-2-((4-(pyridin-2-yl)benzoyl)oxy)butylidene)hydrazine-1-carboxylate→tert-butyl 2-((2S,3S)-3-((tert-butoxycarbonyl)amino)-4-phenyl-2-((4-(pyridin-2-yl)benzoyl)oxy)butyl)hydrazine-1-carboxylate→tert-butyl 2-((2S,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzoyl)hydrazine-1-carboxylate
L-phenylalanine→tert-butyl ((2S,4S,5S)-5-amino-4-hydroxy-1,6-diphenylhexan-2-yl)carbamate succinate→(S)-2-amino-3-phenylpropan-1-ol→(S)-1-chloro-3-phenylpropan-2-amine→(S)-tert-butyl (1-chloro-3-phenylpropan-2-yl)carbamate→(S)-tert-butyl (1-cyano-3-phenylpropan-2-yl)carbamate→(S)-tert-butyl (1-oxo-3-phenylpropan-2-yl)carbamate→(2-nitroethyl)benzene→tert-butyl ((2S,4S,5S)-4-hydroxy-5-nitro-1,6-diphenylhexan-2-yl)carbamate→tert-butyl ((2S,4S,5S)-5-amino-4-hydroxy-1,6-diphenylhexan-2-yl)carbamate
L-phenylalanine→tert-butyl ((2S,4S,5S)-5-amino-4-hydroxy-1,6-diphenylhexan-2-yl)carbamate succinate→(S)-2-amino-3-phenylpropan-1-ol→(S)-1-chloro-3-phenylpropan-2-amine→(S)-tert-butyl (1-chloro-3-phenylpropan-2-yl)carbamate→(S)-tert-butyl (1-cyano-3-phenylpropan-2-yl)carbamate→(S)-tert-butyl (1-oxo-3-phenylpropan-2-yl)carbamate→(2-nitroethyl)benzene→tert-butyl ((2S,4S,5S)-4-hydroxy-5-nitro-1,6-diphenylhexan-2-yl)carbamate→tert-butyl ((2S,4S,5S)-5-amino-4-hydroxy-1,6-diphenylhexan-2-yl)carbamate
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