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CAS 76-42-6
(4R,4aS,7aR,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one
Codes: Naloxone-003, Oxycodone
Application context (from source-drug indications)
PainNaloxone Hydrochloride/Oxycodone Hydrochloride HydrateRestless legs syndromeNaloxone Hydrochloride/Oxycodone Hydrochloride HydrateCancer painNaloxone Hydrochloride/Oxycodone Hydrochloride HydrateChronic painNaloxone Hydrochloride/Oxycodone Hydrochloride HydrateOsteoarthritisNaloxone Hydrochloride/Oxycodone Hydrochloride HydrateLow back painNaloxone Hydrochloride/Oxycodone Hydrochloride HydrateOpioid dependenceNaloxone Hydrochloride中毒Naloxone Hydrochloride心脏停搏Naloxone HydrochloridePainNaloxone Hydrochloride院外心脏骤停Naloxone Hydrochloride急性疼痛Naloxone HydrochloridePainOxycodone Hydrochloride Hydrate急性疼痛Oxycodone Hydrochloride HydrateChronic painOxycodone Hydrochloride HydratePostoperative painOxycodone Hydrochloride Hydrate呼吸障碍Oxycodone Hydrochloride HydrateAnxiety disorderOxycodone Hydrochloride Hydrate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Naloxone Hydrochloride/Oxycodone Hydrochloride Hydrate | Tier C — Watch / trade | - |
| Naloxone Hydrochloride | Tier C — Watch / trade | - |
| Oxycodone Hydrochloride Hydrate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Naloxone Hydrochloride/Oxycodone Hydrochloride HydrateOptimised routesteps: 2total yield: 1.51 g (Oxycodone)
(4R,7aR,12bS)-7,9-dimethoxy-3-methyl-2,3,4,7a-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline→(4R,4aS,7aR,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,3,4,4a-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one→(4R,4aS,7aR,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one
(4R,7aR,12bS)-7,9-dimethoxy-3-methyl-2,3,4,7a-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline→(4R,4aS,7aR,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,3,4,4a-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one→(4R,4aS,7aR,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one
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