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CAS 787635-22-7
tert-butyl (3S)-3-benzyl-4-((3aS,6R)-8,8-dimethyl-2,2-dioxidotetrahydro-3H-3a,6-methanobenzo[c]isothiazol-1(4H)-yl)-4-oxobutanoate
Codes: MITI-030
Application context (from source-drug indications)
Type 2 diabetesMitiglinideDiabetesMitiglinide
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Mitiglinide | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(3aR,7aS)-octahydro-1H-isoindole→(S)-2-benzyl-4-((3aR,7aS)-octahydro-2H-isoindol-2-yl)-4-oxobutanoic acid→tert-butyl 2-bromoacetate→(3aS,6R)-8,8-dimethylhexahydro-3H-3a,6-methanobenzo[c]isothiazole 2,2-dioxide→3-phenylpropanoyl chloride→1-((3aS,6R)-8,8-dimethyl-2,2-dioxidotetrahydro-3H-3a,6-methanobenzo[c]isothiazol-1(4H)-yl)-3-phenylpropan-1-one→tert-butyl (3S)-3-benzyl-4-((3aS,6R)-8,8-dimethyl-2,2-dioxidotetrahydro-3H-3a,6-methanobenzo[c]isothiazol-1(4H)-yl)-4-oxobutanoate→(3S)-3-benzyl-4-((3aS,6R)-8,8-dimethyl-2,2-dioxidotetrahydro-3H-3a,6-methanobenzo[c]isothiazol-1(4H)-yl)-4-oxobutanoic acid→(2S)-2-benzyl-1-((3aS,6R)-8,8-dimethyl-2,2-dioxidotetrahydro-3H-3a,6-methanobenzo[c]isothiazol-1(4H)-yl)-4-((3aR,7aS)-octahydro-2H-isoindol-2-yl)butane-1,4-dione
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