CAS 85583-54-6

5-ethyl-2-(2-(4-nitrophenoxy)ethyl)pyridine

Codes：PIOG-003

Application context (from source-drug indications)

二型糖尿病苯甲酸阿格列汀/盐酸吡格列酮

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
苯甲酸阿格列汀/盐酸吡格列酮Alogliptin Benzoate/Pioglitazone Hydrochloride	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

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苯甲酸阿格列汀/盐酸吡格列酮原研路线steps: 5total yield: 20.50 g

2-(5-ethylpyridin-2-yl)ethan-1-ol→4-nitrophenol→5-ethyl-2-(2-(4-nitrophenoxy)ethyl)pyridine→4-(2-(5-ethylpyridin-2-yl)ethoxy)aniline→ethyl acrylate→ethyl 2-bromo-3-(4-(2-(5-ethylpyridin-2-yl)ethoxy)phenyl)propanoate→thiourea→5-(4-(2-(5-ethylpyridin-2-yl)ethoxy)benzyl)-4-iminothiazolidin-2-one

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