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CAS 869487-76-3

benzyl (S)-(2,6-dimethyl-3-oxohept-1-en-4-yl)carbamate

CodesCARF-026

Application context (from source-drug indications)

多发性骨髓瘤卡非佐米

Source drugs (routes using this intermediate)

DrugTierExpiry
卡非佐米CarfilzomibTier B — Position early2029

Position in synthesis routes (up/downstream chain)

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卡非佐米优化路线steps: 3total yield: 3.18 g
benzyl (S)-(2,6-dimethyl-3-oxohept-1-en-4-yl)carbamatebenzyl ((3R,4S)-3-hydroxy-2,6-dimethylhept-1-en-4-yl)carbamatebenzyl ((3S,4S)-3-hydroxy-2,6-dimethylhept-1-en-4-yl)carbamatebenzyl ((1S,2S)-1-hydroxy-4-methyl-1-((R)-2-methyloxiran-2-yl)pentan-2-yl)carbamatebenzyl ((1R,2S)-1-hydroxy-4-methyl-1-((S)-2-methyloxiran-2-yl)pentan-2-yl)carbamatebenzyl ((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate

Intermediates available on this site

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SupplierProductPrice bandMOQLead timeQualifications
Unibest Nantong cGMP SiteCarbaMic acid, N-[(1S)-3-Methyl-1-[[(2R)-2-Methyl-2-oxiranyl]carbonyl]butyl]-, 1,1-diMethylethyl ester
Pharmaceutical Intermediates
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Unibest Taizhou GMP-like Site1-Pentanone, 2-aMino-4-Methyl-1-[(2R)-2-Methyloxiranyl]-, (2S)-, trifluoroacetate (9CI)
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Qualified Partner — East China API Works(alphaS)-alpha-Aminobenzenebutanoyl-L-leucyl-L-phenylalanine methyl ester
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Unibest Nantong cGMP Site(alphaS)-alpha-Aminobenzenebutanoyl-L-leucyl-L-phenylalanine methyl ester mono(trifluoroacetate)
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Unibest Taizhou GMP-like Site(alphaS)-alpha-[[2-(4-Morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-L-phenylalanine methyl ester
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