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卡非佐米
Tier B — Position earlyCarfilzomib · all drugs expiring in 2029 →
Onyx Pharmaceuticals Inc
Originator
2012
First approval
2029
Expiry (public)
$1.57B ▲
Peak sales
化学药
Type
Targets：Proteasome
Brand：凯洛斯、Kyprolis
Indications (approved)：多发性骨髓瘤
Regional status
US
批准上市
2012-07-20
EU
批准上市
2015-11-19
China
批准上市
2021-07-06
Japan
批准上市
2016-07-04
Synthetic routes & intermediates3 routes
Originator routes × 1Optimised (non-patent) × 2Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OriginatorRoute 1Steps 10 · Total yield 0.08 g
| Code | CAS No. | Intermediate |
|---|---|---|
| CARF-001 | 13139-15-6Available | (tert-butoxycarbonyl)-L-leucine |
| CARF-002 | 962-39-0Available | benzyl L-phenylalaninate |
| CARF-003 | 70637-26-2Available | benzyl (tert-butoxycarbonyl)-L-leucyl-L-phenylalaninate |
| CARF-004 | 70637-28-4Available | (S)-1-(((S)-1-(benzyloxy)-1-oxo-3-phenylpropan-2-yl)amino)-4-methyl-1-oxopentan-2-aminium 2,2,2-trifluoroacetate |
| CARF-005 | 100564-78-1Available | (S)-2-((tert-butoxycarbonyl)amino)-4-phenylbutanoic acid |
| CARF-006 | 868540-15-2Available | benzyl ((S)-2-((tert-butoxycarbonyl)amino)-4-phenylbutanoyl)-L-leucyl-L-phenylalaninate |
| CARF-007 | 875309-83-4Available | (S)-1-(((S)-1-(((S)-1-(benzyloxy)-1-oxo-3-phenylpropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-1-oxo-4-phenylbutan-2-aminium 2,2,2-trifluoroacetate |
| CARF-008 | 3235-69-6Available | 2-morpholinoacetic acid |
| CARF-009 | 875309-92-5Available | benzyl ((S)-2-(2-morpholinoacetamido)-4-phenylbutanoyl)-L-leucyl-L-phenylalaninate |
| CARF-010 | 868540-16-3Available | ((S)-2-(2-morpholinoacetamido)-4-phenylbutanoyl)-L-leucyl-L-phenylalanine |
| CARF-011 | 247068-85-5Available | (S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-aminium 2,2,2-trifluoroacetate |
| CARF-012 | 87694-50-6Available | tert-butyl (S)-(1-(methoxy(methyl)amino)-4-methyl-1-oxopentan-2-yl)carbamate |
| CARF-013 | 557-93-7Available | 2-bromoprop-1-ene |
| CARF-014 | 247068-81-1Available | tert-butyl (S)-(2,6-dimethyl-3-oxohept-1-en-4-yl)carbamate |
| CARF-015 | 247068-82-2Available | tert-butyl ((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate |
OptimisedRoute 2Steps 11 · Total yield 13.5 g
| Code | CAS No. | Intermediate |
|---|---|---|
| CARF-001 | 13139-15-6Available | (tert-butoxycarbonyl)-L-leucine |
| CARF-005 | 100564-78-1Available | (S)-2-((tert-butoxycarbonyl)amino)-4-phenylbutanoic acid |
| CARF-010 | 868540-16-3Available | ((S)-2-(2-morpholinoacetamido)-4-phenylbutanoyl)-L-leucyl-L-phenylalanine |
| CARF-011 | 247068-85-5Available | (S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-aminium 2,2,2-trifluoroacetate |
| CARF-012 | 87694-50-6Available | tert-butyl (S)-(1-(methoxy(methyl)amino)-4-methyl-1-oxopentan-2-yl)carbamate |
| CARF-014 | 247068-81-1Available | tert-butyl (S)-(2,6-dimethyl-3-oxohept-1-en-4-yl)carbamate |
| CARF-015 | 247068-82-2Available | tert-butyl ((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate |
| CARF-016 | 2577-90-4Available | (S)-methyl 2-amino-3-phenylpropanoate |
| CARF-017 | 5874-73-7Available | methyl (tert-butoxycarbonyl)-L-leucyl-L-phenylalaninate |
| CARF-018 | 90072-18-7Available | (S)-1-(((S)-1-methoxy-1-oxo-3-phenylpropan-2-yl)amino)-4-methyl-1-oxopentan-2-aminium 2,2,2-trifluoroacetate |
| CARF-019 | 868539-96-2Available | methyl ((S)-2-((tert-butoxycarbonyl)amino)-4-phenylbutanoyl)-L-leucyl-L-phenylalaninate |
| CARF-020 | 79-04-9Available | 2-chloroacetyl chloride |
| CARF-021 | 868540-08-3Available | methyl ((S)-2-(2-chloroacetamido)-4-phenylbutanoyl)-L-leucyl-L-phenylalaninate |
| CARF-022 | 110-91-8Available | morpholine |
| CARF-023 | 1140908-89-9Available | methyl ((S)-2-(2-morpholinoacetamido)-4-phenylbutanoyl)-L-leucyl-L-phenylalaninate |
| CARF-024 | 6638-79-5Available | N,O-dimethylhydroxylamine hydrochloride |
| CARF-025 | 13291-18-4Available | prop-1-en-2-ylmagnesium bromide |
OptimisedRoute 3Steps 3 · Total yield 3.18 g
| Code | CAS No. | Intermediate |
|---|---|---|
| CARF-026 | 869487-76-3Available | benzyl (S)-(2,6-dimethyl-3-oxohept-1-en-4-yl)carbamate |
| CARF-027 | 869487-77-4Available | benzyl ((3R,4S)-3-hydroxy-2,6-dimethylhept-1-en-4-yl)carbamate |
| CARF-028 | - | benzyl ((3S,4S)-3-hydroxy-2,6-dimethylhept-1-en-4-yl)carbamate |
| CARF-029 | 869487-78-5Available | benzyl ((1S,2S)-1-hydroxy-4-methyl-1-((R)-2-methyloxiran-2-yl)pentan-2-yl)carbamate |
| CARF-030 | - | benzyl ((1R,2S)-1-hydroxy-4-methyl-1-((S)-2-methyloxiran-2-yl)pentan-2-yl)carbamate |
| CARF-031 | 869487-79-6Available | benzyl ((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate |
Frequently asked questions
What are the approved indications of Carfilzomib?
Approved indications include: 多发性骨髓瘤.
When does the Carfilzomib patent expire?
Based on public sources, the Carfilzomib patent expires in 2029.
How many synthesis routes are recorded for Carfilzomib?
3 synthesis routes are recorded; the shortest is 3 steps with 3.18 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Carfilzomib intermediates?
29 intermediate CAS of Carfilzomib are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Carfilzomib intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24