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CAS 869494-16-6
tert-butyl 3,6-diazabicyclo[3.1.1]heptane-6-carboxylate
Codes：SELP-019
Application context (from source-drug indications)
实体瘤塞普替尼甲状腺髓样癌塞普替尼非小细胞肺癌塞普替尼甲状腺瘤塞普替尼
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 塞普替尼Selpercatinib | Tier C — Watch / trade | 2032 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-(6-fluoropyridin-3-yl)-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile→tert-butyl 3,6-diazabicyclo[3.1.1]heptane-6-carboxylate→tert-butyl 3-(5-(3-cyano-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridin-4-yl)pyridin-2-yl)-3,6-diazabicyclo[3.1.1]heptane-6-carboxylate→4-(6-(3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile→6-methoxynicotinaldehyde→tert-butyl hydroxycarbamate→2,4,6-trimethylbenzenesulfonyl chloride→tert-butyl ((mesitylsulfonyl)oxy)carbamate→O-(mesitylsulfonyl)hydroxylamine→3-bromo-5-methoxypyridine→1-amino-3-bromo-5-methoxypyridin-1-ium 2,4,6-trimethylbenzenesulfonate→ethyl propiolate→ethyl 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carboxylate→ethyl 4-bromo-6-methoxypyrazolo[1,5-a]pyridine-3-carboxylate→4-bromo-6-methoxypyrazolo[1,5-a]pyridine→4-bromo-6-methoxypyrazolo[1,5-a]pyridine-3-carbaldehyde→(E)-4-bromo-6-methoxypyrazolo[1,5-a]pyridine-3-carbaldehyde oxime→4-bromo-6-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile→4-bromo-6-hydroxypyrazolo[1,5-a]pyridine-3-carbonitrile→2,2-dimethyloxirane→4-bromo-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile→2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Intermediates available on this site
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| Supplier | Product | Price band | MOQ | Lead time | Qualifications |
|---|---|---|---|---|---|
| Unibest Taizhou GMP-like Site | Tert-butyl 3,6-diazabicyclo[3.1.1]heptane-6-carboxylate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
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