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CAS 87-61-6

1,2,3-trichlorobenzene

Codes: ANAG-006, ANAG-007

Application context (from source-drug indications)

Essential thrombocythaemiaAnagrelide Hydrochloride HydrateMyeloproliferative neoplasmAnagrelide Hydrochloride Hydrate血小板增多Anagrelide Hydrochloride HydrateMyelofibrosisAnagrelide Hydrochloride HydrateChronic myeloid leukaemiaAnagrelide Hydrochloride HydratePolycythaemia veraAnagrelide Hydrochloride Hydrate

Source drugs (routes using this intermediate)

DrugTierExpiry
Anagrelide Hydrochloride HydrateTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Anagrelide Hydrochloride HydrateOptimised routesteps: 7total yield: /
1,2,3-trichlorobenzene→1,2,3-trichlorobenzene→2,3-dichloro-6-nitrobenzonitrile→(2,3-dichloro-6-nitrophenyl)methanamine→ethyl 2-bromoacetate→ethyl 2-((2,3-dichloro-6-nitrobenzyl)amino)acetate→ethyl 2-((6-amino-2,3-dichlorobenzyl)amino)acetate→6,7-dichloro-3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one hydrobromide

Intermediates available on this site

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