CAS 870-50-8

di-tert-butyl (E)-diazene-1,2-dicarboxylate

Codes：ESKE-008

Application context (from source-drug indications)

重度抑郁症盐酸艾司氯胺酮自杀意念盐酸艾司氯胺酮抑郁症盐酸艾司氯胺酮麻醉盐酸艾司氯胺酮难治性抑郁症盐酸艾司氯胺酮疼痛盐酸艾司氯胺酮

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
盐酸艾司氯胺酮Esketamine Hydrochloride	Tier B — Position early	2029

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

盐酸艾司氯胺酮优化路线steps: 4total yield: 6.60 mg (Esketamine Hydrochloride)

1-chloro-2-iodobenzene→cyclohexanone→2-(2-chlorophenyl)cyclohexan-1-one→di-tert-butyl (E)-diazene-1,2-dicarboxylate→di-tert-butyl (S)-1-(1-(2-chlorophenyl)-2-oxocyclohexyl)hydrazine-1,2-dicarboxylate→(S)-2-amino-2-(2-chlorophenyl)cyclohexan-1-one

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