CAS 615-41-8

1-chloro-2-iodobenzene1-Chloro-2-iodobenzene

Codes：ESKE-005、(I)270899-2-a、Levamlodipine Besylate-013

Application context (from source-drug indications)

重度抑郁症盐酸艾司氯胺酮自杀意念盐酸艾司氯胺酮抑郁症盐酸艾司氯胺酮麻醉盐酸艾司氯胺酮难治性抑郁症盐酸艾司氯胺酮疼痛盐酸艾司氯胺酮高血压苯磺酸左旋氨氯地平心绞痛苯磺酸左旋氨氯地平原发性高血压苯磺酸左旋氨氯地平

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
盐酸艾司氯胺酮Esketamine Hydrochloride	Tier B — Position early	2029
苯磺酸左旋氨氯地平Levamlodipine Besylate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

盐酸艾司氯胺酮优化路线steps: 4total yield: 6.60 mg (Esketamine Hydrochloride)

1-chloro-2-iodobenzene→cyclohexanone→2-(2-chlorophenyl)cyclohexan-1-one→di-tert-butyl (E)-diazene-1,2-dicarboxylate→di-tert-butyl (S)-1-(1-(2-chlorophenyl)-2-oxocyclohexyl)hydrazine-1,2-dicarboxylate→(S)-2-amino-2-(2-chlorophenyl)cyclohexan-1-one

盐酸艾司氯胺酮优化路线steps: 4total yield: /

1-Chloro-2-iodobenzene→4-Cyclohexanone→2-(2-Chlorophenyl)cyclohexanone→(E)-Di-tert-butyl azodiformate→Di-tert-butyl 1-[(1S)-1-(2-chlorophenyl)-2-oxocyclohexyl]hydrazine-1,2-dicarboxylate→(-)-2(S)-Amino-2-(2-chlorophenyl)cyclohexanone→(1S)-2'-Chloro-1-isocyanato-6-methoxy-1,2,3,4-tetrahydro-1,1'-biphenyl→Formaldehyde→(2S)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone

苯磺酸左旋氨氯地平优化路线steps: 2total yield: 9.98g(Amlodipine (Free))

1-tert-Butyl 3-ethyl 5-methyl 2-([2-[(tert-butoxycarbonyl)amino]ethoxy]methyl)-6-methylpyridine-1,3,5(4H)-tricarboxylate→1-Chloro-2-iodobenzene→2-(2-Chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane→2-(2-Chlorophenyl)-4,4-dimethyl-1,3,2-dioxaborolane→2-(2-Chlorophenyl)-1,3,2-dioxaborolane→1-tert-Butyl 3-ethyl 5-methyl 2-([2-[(tert-butoxycarbonyl)amino]ethoxy]methyl)-4-(2-chlorophenyl)-6-methylpyridine-1,3,5(4H)-tricarboxylate→(±)-2-(2-Aminoethoxymethyl)-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

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