← Back to patent-cliff list
CAS 877758-94-6
7-Chloro-2-[(1S)-2,2-dimethylcyclopropylcarboxamido]-2-heptenoic acid ethyl ester
Codes: Cilastatin Sodium-010
Application context (from source-drug indications)
Infectious diseaseCilastatin Sodium
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Cilastatin Sodium | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Ethyl 7-chloro-2-oxoheptanoate→(+)-(1S)-2,2-Dimethylcyclopropanecarboxamide→7-Chloro-2-[(1S)-2,2-dimethylcyclopropylcarboxamido]-2-heptenoic acid ethyl ester→7-Chloro-2-[(1S)-2,2-dimethylcyclopropylcarboxamido]-2(Z)-heptenoic acid sodium salt→(R)-Cysteine hydrochloride monohydrate
1-Bromo-5-chloropentane→Ethyl 2-ethoxy-2-oxoacetate→7-Chloro-2-oxoheptanoic acid ethyl ester→Ethyl 7-bromo-2-oxoheptanoate→Butyl 7-chloro-2-oxoheptanoate→2,2-Dimethylcyclopropane-1(S)-carboxamide→7-Chloro-2-[(1S)-2,2-dimethylcyclopropylcarboxamido]-2-heptenoic acid ethyl ester→Ethyl (2Z)-7-bromo-2-([[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino)hept-2-enoate→Butyl (2Z)-7-chloro-2-[[(1S)-2,2-dimethylcyclopropane-1-carbonyl]amino]hept-2-enoate→(2Z)-7-Chloro-2-([[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino)hept-2-enoic acid→(2Z)-7-Bromo-2-([[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino)hept-2-enoic acid→L-Cysteine→(2Z)-7-[[(2R)-2-Amino-2-carboxyethyl]sulfanyl]-2-([[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino)hept-2-enoic acid
Ethyl 7-chloro-2-oxoheptanoate→(+)-(1S)-2,2-Dimethylcyclopropanecarboxamide→7-Chloro-2-[(1S)-2,2-dimethylcyclopropylcarboxamido]-2-heptenoic acid ethyl ester→2-[(1S)-2,2-Dimethylcyclopropylcarboxamido]-7-iodo-2-heptenoic acid ethyl ester→L-Cysteine methyl ester hydrochloride→7-[2(R)-Amino-3-methoxy-3-oxopropylsulfanyl]-2-(2,2-dimethylcyclopropylcarboxamido)-2-heptenoic acid ethyl ester
Intermediates available on this site
No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.