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Cilastatin Sodium
Tier C — Watch / tradeCilastatin Sodium
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Originator
2000
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：Enzymes
Indications (approved)：Infectious disease
Regional status
US
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EU
-
China
Approved
2000-05-27
Japan
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Synthetic routes & intermediates6 routes
Originator routes × 0Optimised (non-patent) × 6Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 5 · Total yield 95g(Cilastatin Sodium (Free))
Cilastatin Sodium-00120462-00-4Cilastatin Sodium-002111-24-0Cilastatin Sodium-003107871-16-9Cilastatin Sodium-004107871-17-0Cilastatin Sodium-005107872-93-5Cilastatin Sodium-00675885-58-4Cilastatin Sodium-00778834-80-7Cilastatin Sodium-00852-90-4API · Cilastatin Sodium
| Code | CAS No. | Intermediate |
|---|---|---|
| Cilastatin Sodium-001 | 20462-00-4 | Ethyl 1,3-dithiane-2-carboxylate |
| Cilastatin Sodium-002 | 111-24-0 | Pentamethylene dibromide |
| Cilastatin Sodium-003 | 107871-16-9 | ethyl 2-(5-bromopentyl)-1,3-dithiane-2-carboxylate |
| Cilastatin Sodium-004 | 107871-17-0 | Ethyl 7-bromo-2-oxoheptanoate |
| Cilastatin Sodium-005 | 107872-93-5 | 7-bromo-2-oxoheptanoic acid |
| Cilastatin Sodium-006 | 75885-58-4 | (+)-(1S)-2,2-Dimethylcyclopropanecarboxamide |
| Cilastatin Sodium-007 | 78834-80-7 | (2Z)-7-Bromo-2-([[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino)hept-2-enoic acid |
| Cilastatin Sodium-008 | 52-90-4 | Plant-derived natural amino-acid L-cysteine |
OptimisedRoute 2Steps 3 · Total yield 19.352g(Cilastatin Sodium (API))
Cilastatin Sodium-00978834-75-0Cilastatin Sodium-00675885-58-4Cilastatin Sodium-010877758-94-6Cilastatin Sodium-011—Cilastatin Sodium-01252-89-1,7048-04-6API · Cilastatin Sodium
| Code | CAS No. | Intermediate |
|---|---|---|
| Cilastatin Sodium-009 | 78834-75-0 | Ethyl 7-chloro-2-oxoheptanoate |
| Cilastatin Sodium-006 | 75885-58-4 | (+)-(1S)-2,2-Dimethylcyclopropanecarboxamide |
| Cilastatin Sodium-010 | 877758-94-6 | 7-Chloro-2-[(1S)-2,2-dimethylcyclopropylcarboxamido]-2-heptenoic acid ethyl ester |
| Cilastatin Sodium-011 | - | 7-Chloro-2-[(1S)-2,2-dimethylcyclopropylcarboxamido]-2(Z)-heptenoic acid sodium salt |
| Cilastatin Sodium-012 | 52-89-1,7048-04-6 | (R)-Cysteine hydrochloride monohydrate |
OptimisedRoute 3Steps 6 · Total yield 20.8g(Cilastatin Sodium (API))
Cilastatin Sodium-01354512-75-3Cilastatin Sodium-01495-92-1Cilastatin Sodium-00978834-75-0Cilastatin Sodium-004107871-17-0Cilastatin Sodium-0151401730-37-7Cilastatin Sodium-00675885-58-4Cilastatin Sodium-010877758-94-6Cilastatin Sodium-0161401730-23-1Cilastatin Sodium-017—Cilastatin Sodium-018877674-77-6Cilastatin Sodium-00778834-80-7Cilastatin Sodium-00852-90-4Cilastatin Sodium-01982009-34-5API · Cilastatin Sodium
| Code | CAS No. | Intermediate |
|---|---|---|
| Cilastatin Sodium-013 | 54512-75-3 | 1-Bromo-5-chloropentane |
| Cilastatin Sodium-014 | 95-92-1 | Ethyl 2-ethoxy-2-oxoacetate |
| Cilastatin Sodium-009 | 78834-75-0 | 7-Chloro-2-oxoheptanoic acid ethyl ester |
| Cilastatin Sodium-004 | 107871-17-0 | Ethyl 7-bromo-2-oxoheptanoate |
| Cilastatin Sodium-015 | 1401730-37-7 | Butyl 7-chloro-2-oxoheptanoate |
| Cilastatin Sodium-006 | 75885-58-4 | 2,2-Dimethylcyclopropane-1(S)-carboxamide |
| Cilastatin Sodium-010 | 877758-94-6 | 7-Chloro-2-[(1S)-2,2-dimethylcyclopropylcarboxamido]-2-heptenoic acid ethyl ester |
| Cilastatin Sodium-016 | 1401730-23-1 | Ethyl (2Z)-7-bromo-2-([[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino)hept-2-enoate |
| Cilastatin Sodium-017 | - | Butyl (2Z)-7-chloro-2-[[(1S)-2,2-dimethylcyclopropane-1-carbonyl]amino]hept-2-enoate |
| Cilastatin Sodium-018 | 877674-77-6 | (2Z)-7-Chloro-2-([[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino)hept-2-enoic acid |
| Cilastatin Sodium-007 | 78834-80-7 | (2Z)-7-Bromo-2-([[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino)hept-2-enoic acid |
| Cilastatin Sodium-008 | 52-90-4 | L-Cysteine |
| Cilastatin Sodium-019 | 82009-34-5 | (2Z)-7-[[(2R)-2-Amino-2-carboxyethyl]sulfanyl]-2-([[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino)hept-2-enoic acid |
OptimisedRoute 4Steps 4 · Total yield 615.03mg(Cilastatin Sodium (API))
Cilastatin Sodium-00978834-75-0Cilastatin Sodium-00675885-58-4Cilastatin Sodium-010877758-94-6Cilastatin Sodium-0201251921-38-6Cilastatin Sodium-02118598-63-5Cilastatin Sodium-0221251921-39-7API · Cilastatin Sodium
| Code | CAS No. | Intermediate |
|---|---|---|
| Cilastatin Sodium-009 | 78834-75-0 | Ethyl 7-chloro-2-oxoheptanoate |
| Cilastatin Sodium-006 | 75885-58-4 | (+)-(1S)-2,2-Dimethylcyclopropanecarboxamide |
| Cilastatin Sodium-010 | 877758-94-6 | 7-Chloro-2-[(1S)-2,2-dimethylcyclopropylcarboxamido]-2-heptenoic acid ethyl ester |
| Cilastatin Sodium-020 | 1251921-38-6 | 2-[(1S)-2,2-Dimethylcyclopropylcarboxamido]-7-iodo-2-heptenoic acid ethyl ester |
| Cilastatin Sodium-021 | 18598-63-5 | L-Cysteine methyl ester hydrochloride |
| Cilastatin Sodium-022 | 1251921-39-7 | 7-[2(R)-Amino-3-methoxy-3-oxopropylsulfanyl]-2-(2,2-dimethylcyclopropylcarboxamido)-2-heptenoic acid ethyl ester |
OptimisedRoute 5Steps 1 · Total yield 18.6g(Cilastatin Sodium-024)
Cilastatin Sodium-023141-97-9Cilastatin Sodium-01354512-75-3Cilastatin Sodium-024136879-36-2API · Cilastatin Sodium
| Code | CAS No. | Intermediate |
|---|---|---|
| Cilastatin Sodium-023 | 141-97-9Available | Ethyl 3-oxobutanoate |
| Cilastatin Sodium-013 | 54512-75-3 | 1-Bromo-5-chloropentane |
| Cilastatin Sodium-024 | 136879-36-2 | Ethyl 2-acetyl-7-chloroheptanoate |
OptimisedRoute 6Steps 6 · Total yield 1.45g(Cilastatin Sodium-030)
Cilastatin Sodium-025924-50-5Cilastatin Sodium-02674-95-3Cilastatin Sodium-027932-58-1Cilastatin Sodium-02875885-59-5Cilastatin Sodium-02950675-57-5Cilastatin Sodium-03014590-53-5Cilastatin Sodium-031623-73-4Cilastatin Sodium-032115-11-7Cilastatin Sodium-03389007-61-4Cilastatin Sodium-034—API · Cilastatin Sodium
| Code | CAS No. | Intermediate |
|---|---|---|
| Cilastatin Sodium-025 | 924-50-5 | Methyl 3,3-dimethylacrylate |
| Cilastatin Sodium-026 | 74-95-3 | Dibromomethane |
| Cilastatin Sodium-027 | 932-58-1 | Methyl 2,2-dimethylcyclopropane-1-carboxylate |
| Cilastatin Sodium-028 | 75885-59-5 | 2,2-Dimethylcyclopropane-1-carboxylic acid |
| Cilastatin Sodium-029 | 50675-57-5 | 2,2-Dimethylcyclopropane-1-carbonyl chloride |
| Cilastatin Sodium-030 | 14590-53-5 | (S)-2,2-Dimethylcyclopropanecarboxylic acid |
| Cilastatin Sodium-031 | 623-73-4 | Ethyl 2-diazoacetate |
| Cilastatin Sodium-032 | 115-11-7 | 2-Methyl-1-propene |
| Cilastatin Sodium-033 | 89007-61-4 | Ethyl (1S)-2,2-dimethylcyclopropane-1-carboxylate |
| Cilastatin Sodium-034 | - | (4R)-4-(1-methylcycloprop-2-en-1-yl)-2-(1-((R)-4-(tert-pentyl)-4,5-dihydrooxazol-2-yl)-1-tritetracontaoxidanylethyl)-4,5-dihydrooxazole |
Frequently asked questions
What are the approved indications of Cilastatin Sodium?
Approved indications include: Infectious disease.
When does the Cilastatin Sodium patent expire?
No public expiry year is available for Cilastatin Sodium yet; this page updates once verified.
How many synthesis routes are recorded for Cilastatin Sodium?
6 synthesis routes are recorded; the shortest is 1 steps with 18.6g(Cilastatin Sodium-024) total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Cilastatin Sodium intermediates?
1 intermediate CAS of Cilastatin Sodium are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Cilastatin Sodium intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-27