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CAS 88-18-6
2-(tert-butyl)phenol
Codes：DASA-001
Application context (from source-drug indications)
慢性丙型肝炎达塞布韦钠丙型肝炎达塞布韦钠失代偿性肝硬化达塞布韦钠肾功能不全达塞布韦钠纤维化达塞布韦钠终末期肾脏病达塞布韦钠
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 达塞布韦钠Dasabuvir Sodium Hydrate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→2-(tert-butyl)phenol→2-(tert-butyl)-4-nitrophenol→2-bromo-6-(tert-butyl)-4-nitrophenol→1-bromo-3-(tert-butyl)-2-methoxy-5-nitrobenzene→3-bromo-5-(tert-butyl)-4-methoxyaniline→tert-butyl (3-bromo-5-(tert-butyl)-4-methoxyphenyl)carbamate→N-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalen-2-yl)methanesulfonamide→tert-butyl (3-(tert-butyl)-4-methoxy-5-(6-(methylsulfonamido)naphthalen-2-yl)phenyl)carbamate→N-(6-(5-amino-3-(tert-butyl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide→(E)-3-methoxyacryloyl isocyanate→(E)-N-((3-(tert-butyl)-4-methoxy-5-(6-(methylsulfonamido)naphthalen-2-yl)phenyl)carbamoyl)-3-methoxyacrylamide→methyl 6-bromo-2-naphthoate→6-bromo-2-naphthoic acid→6-bromonaphthalen-2-amine→N-(6-bromonaphthalen-2-yl)methanesulfonamide
2-(tert-butyl)phenol→2-(tert-butyl)-4-nitrophenol→N-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalen-2-yl)methanesulfonamide→(E)-3-methoxyacryloyl isocyanate→1-(3-(tert-butyl)-5-iodo-4-methoxyphenyl)pyrimidine-2,4(1H,3H)-dione→2-(tert-butyl)-6-iodo-4-nitrophenol→1-(tert-butyl)-3-iodo-2-methoxy-5-nitrobenzene→3-(tert-butyl)-5-iodo-4-methoxyaniline→(E)-N-((3-(tert-butyl)-5-iodo-4-methoxyphenyl)carbamoyl)-3-methoxyacrylamide
2-(tert-butyl)phenol→2-(tert-butyl)-4,6-diiodophenol→1-(tert-butyl)-3,5-diiodo-2-methoxybenzene→pyrimidine-2,4(1H,3H)-dione→1-(3-(tert-butyl)-5-iodo-4-methoxyphenyl)pyrimidine-2,4(1H,3H)-dione→(6-hydroxynaphthalen-2-yl)boronic acid→1-(3-(tert-butyl)-5-(6-hydroxynaphthalen-2-yl)-4-methoxyphenyl)pyrimidine-2,4(1H,3H)-dione→6-[3-Tert-Butyl-5-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)-2-Methoxyphenyl]-2-Naphthyl 1,1,2,2,3,3,4,4,4-Nonafluorobutane-1-Sulfonate→methanesulfonamide
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