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CAS 88150-45-2

ethyl 4-(2-azidoethoxy)-3-oxobutanoate

Codes：(III)109067-1-a、(III)109067-3-a

Application context (from source-drug indications)

高血压Olmesartan Medoxomil/Amlodipine orotate原发性高血压缬沙坦/氨氯地平乳清酸盐

Source drugs (routes using this intermediate)

DrugTierExpiry
Olmesartan Medoxomil/Amlodipine orotateOlmesartan Medoxomil/Amlodipine orotateTier C — Watch / trade-
缬沙坦/氨氯地平乳清酸盐Valsartan/Amlodipine OrotateTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Olmesartan Medoxomil/Amlodipine orotate优化路线steps: 3total yield: /
Ethyl 4-chloro-3-oxobutanoate→2-azidoethan-1-ol→ethyl 4-(2-azidoethoxy)-3-oxobutanoate→3-Amino-2-butenoic acid methyl ester→2-Chlorobenzaldehyde→3-ethyl 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Olmesartan Medoxomil/Amlodipine orotate优化路线steps: 3total yield: /
4-Chloro-3-oxobutyric acid ethyl ester→2-azidoethan-1-ol→ethyl 4-(2-azidoethoxy)-3-oxobutanoate→Methyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate→3-ethyl 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
缬沙坦/氨氯地平乳清酸盐优化路线steps: 3total yield: /
Ethyl 4-chloro-3-oxobutanoate→2-azidoethan-1-ol→ethyl 4-(2-azidoethoxy)-3-oxobutanoate→3-Amino-2-butenoic acid methyl ester→2-Chlorobenzaldehyde→3-ethyl 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
缬沙坦/氨氯地平乳清酸盐优化路线steps: 3total yield: /
4-Chloro-3-oxobutyric acid ethyl ester→2-azidoethan-1-ol→ethyl 4-(2-azidoethoxy)-3-oxobutanoate→Methyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate→3-ethyl 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Intermediates available on this site

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