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CAS 88150-46-3
3-ethyl 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Codes：(VI)109067-1-a、(V)109067-3-a
Application context (from source-drug indications)
高血压Olmesartan Medoxomil/Amlodipine orotate原发性高血压缬沙坦/氨氯地平乳清酸盐
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Olmesartan Medoxomil/Amlodipine orotateOlmesartan Medoxomil/Amlodipine orotate | Tier C — Watch / trade | - |
| 缬沙坦/氨氯地平乳清酸盐Valsartan/Amlodipine Orotate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Ethyl 4-chloro-3-oxobutanoate→2-azidoethan-1-ol→ethyl 4-(2-azidoethoxy)-3-oxobutanoate→3-Amino-2-butenoic acid methyl ester→2-Chlorobenzaldehyde→3-ethyl 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
4-Chloro-3-oxobutyric acid ethyl ester→2-azidoethan-1-ol→ethyl 4-(2-azidoethoxy)-3-oxobutanoate→Methyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate→3-ethyl 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Ethyl 4-chloro-3-oxobutanoate→2-azidoethan-1-ol→ethyl 4-(2-azidoethoxy)-3-oxobutanoate→3-Amino-2-butenoic acid methyl ester→2-Chlorobenzaldehyde→3-ethyl 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
4-Chloro-3-oxobutyric acid ethyl ester→2-azidoethan-1-ol→ethyl 4-(2-azidoethoxy)-3-oxobutanoate→Methyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate→3-ethyl 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
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