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CAS 90315-82-5
Ethyl (R)-(-)-2-hydroxy-4-phenylbutyrate
Codes：Enalapril-012、Enalapril-054
Application context (from source-drug indications)
心脏和血管疾病阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利高血压阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利高脂血症阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利心脏病阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利原发性高血压马来酸依那普利/叶酸
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利Atorvastatin/Hydrochlorothiazide/Aspirin/Enalapril | Tier C — Watch / trade | - |
| 马来酸依那普利/叶酸Enalapril Maleate/Folic Acid | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-Hydroxy-4-phenylbutanenitrile→2(R)-Hydroxy-4-phenylbutanenitrile→4-Phenyl-2(R)-(tetrahydropyran-2-yloxy)butanenitrile→4-Phenyl-2(R)-(tetrahydropyran-2-yloxy)butyric acid→N-[(Benzyloxy)carbonyl]-L-alanine→Ethyl (R)-(-)-2-hydroxy-4-phenylbutyrate→4-Phenyl-2(R)-(trifluoromethylsulfonyloxy)butyric acid ethyl ester→L-Alanyl-L-proline tert-butyl ester→N-[1-Ethoxy-1-oxo-4-phenylbutan-2(S)-yl]-L-alanyl-L-proline tert-butyl ester→N-Boc-proline→N-(Benzyloxycarbonyl)-L-alanyl-L-proline tert-butyl ester
Bitter almond→2-Oxopropionic acid→Potassium (3E)-2-oxo-4-phenylbut-3-enoate→(2R,3E)-2-Hydroxy-4-phenylbut-3-enoic acid→2(R)-Hydroxy-4-phenylbutyric acid→Ethyl (R)-(-)-2-hydroxy-4-phenylbutyrate
3-Phenylpropionaldehyde→Ethyl 2-oxo-4-phenylbut-3-enoate→2(R)-Hydroxy-4-phenylbutanenitrile→Ethyl (R)-(-)-2-hydroxy-4-phenylbutyrate
2-Hydroxy-4-phenylbutanenitrile→2(R)-Hydroxy-4-phenylbutanenitrile→4-Phenyl-2(R)-(tetrahydropyran-2-yloxy)butanenitrile→4-Phenyl-2(R)-(tetrahydropyran-2-yloxy)butyric acid→N-[(Benzyloxy)carbonyl]-L-alanine→Ethyl (R)-(-)-2-hydroxy-4-phenylbutyrate→4-Phenyl-2(R)-(trifluoromethylsulfonyloxy)butyric acid ethyl ester→L-Alanyl-L-proline tert-butyl ester→N-[1-Ethoxy-1-oxo-4-phenylbutan-2(S)-yl]-L-alanyl-L-proline tert-butyl ester→N-Boc-proline→N-(Benzyloxycarbonyl)-L-alanyl-L-proline tert-butyl ester
Bitter almond→2-Oxopropionic acid→Potassium (3E)-2-oxo-4-phenylbut-3-enoate→(2R,3E)-2-Hydroxy-4-phenylbut-3-enoic acid→2(R)-Hydroxy-4-phenylbutyric acid→Ethyl (R)-(-)-2-hydroxy-4-phenylbutyrate
3-Phenylpropionaldehyde→Ethyl 2-oxo-4-phenylbut-3-enoate→2(R)-Hydroxy-4-phenylbutanenitrile→Ethyl (R)-(-)-2-hydroxy-4-phenylbutyrate
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