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CAS 94-05-3
ethyl (Z)-2-cyano-3-ethoxyacrylate
Codes：NERT-028
Application context (from source-drug indications)
乳腺癌马来酸奈拉替尼
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 马来酸奈拉替尼Neratinib Maleate | Tier C — Watch / trade | 2030 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-((2-chloro-4-nitrophenoxy)methyl)pyridine→N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl)acetamide→N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)acetamide→6-amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile→(E)-4-(dimethylamino)but-2-enoic acid hydrochloride→2-amino-5-nitrophenol→N-(2-hydroxy-4-nitrophenyl)acetamide→N-(2-ethoxy-4-nitrophenyl)acetamide→N-(4-amino-2-ethoxyphenyl)acetamide→ethyl (Z)-2-cyano-3-ethoxyacrylate→(Z)-ethyl 3-((4-acetamido-3-ethoxyphenyl)amino)-2-cyanoacrylate→N-(3-cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide
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