马来酸奈拉替尼
Tier C — Watch / tradeNeratinib Maleate · all drugs expiring in 2030 →
Targets：HER4、EGFR、HER2
Brand：贺俪安、汉奈佳、赫赛佳、Nerlynx、Hernera
Indications (approved)：乳腺癌
Regional status
Synthetic routes & intermediates4 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| NERT-001 | 214476-09-2 | 4-chloro-7-ethoxy-6-nitroquinoline-3-carbonitrile |
| NERT-002 | 848133-87-9 | 6-amino-4-chloro-7-ethoxyquinoline-3-carbonitrile |
| NERT-003 | 1056149-69-9 | (E)-4-(dimethylamino)but-2-enoyl chloride |
| NERT-004 | 848133-88-0 | (E)-N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide |
| NERT-005 | 524955-09-7Available | 3-chloro-4-(pyridin-2-ylmethoxy)aniline |
| Code | CAS No. | Intermediate |
|---|---|---|
| NERT-005 | 524955-09-7Available | 3-chloro-4-(pyridin-2-ylmethoxy)aniline |
| NERT-006 | 619-08-9 | 2-chloro-4-nitrophenol |
| NERT-007 | 586-98-1 | pyridin-2-ylmethanol |
| NERT-008 | 179687-79-7 | 2-((2-chloro-4-nitrophenoxy)methyl)pyridine |
| NERT-009 | 848133-76-6Available | N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl)acetamide |
| NERT-010 | 915941-95-6 | N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)acetamide |
| NERT-011 | 848139-78-6Available | 6-amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile |
| NERT-012 | 1632473-08-5 | (E)-4-(dimethylamino)but-2-enoic acid hydrochloride |
| Code | CAS No. | Intermediate |
|---|---|---|
| NERT-005 | 524955-09-7Available | 3-chloro-4-(pyridin-2-ylmethoxy)aniline |
| NERT-013 | 625-35-4 | (E)-but-2-enoyl chloride |
| NERT-014 | 927802-54-8 | methyl 3-amino-4-ethoxybenzoate |
| NERT-015 | 1403831-68-4 | (E)-methyl 3-(but-2-enamido)-4-ethoxybenzoate |
| NERT-016 | 1403831-69-5 | (E)-methyl 5-(but-2-enamido)-4-ethoxy-2-nitrobenzoate |
| NERT-017 | 1403831-70-8 | - |
| NERT-018 | 2032-34-0 | 3,3-diethoxypropanenitrile |
| NERT-019 | 1403831-73-1 | methyl 5-((E)-but-2-enamido)-2-((2-cyanovinyl)amino)-4-ethoxybenzoate |
| NERT-020 | 1403831-74-2 | (E)-N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)but-2-enamide |
| NERT-021 | 1403831-79-7 | (E)-N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl)but-2-enamide |
| NERT-022 | 1403831-80-0 | (E)-N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)but-2-enamide |
| NERT-023 | 1257230-74-2 | (E)-4-bromo-N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)but-2-enamide |
| Code | CAS No. | Intermediate |
|---|---|---|
| NERT-008 | 179687-79-7 | 2-((2-chloro-4-nitrophenoxy)methyl)pyridine |
| NERT-009 | 848133-76-6Available | N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl)acetamide |
| NERT-010 | 915941-95-6 | N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)acetamide |
| NERT-011 | 848139-78-6Available | 6-amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile |
| NERT-012 | 1632473-08-5 | (E)-4-(dimethylamino)but-2-enoic acid hydrochloride |
| NERT-024 | 121-88-0 | 2-amino-5-nitrophenol |
| NERT-025 | 25351-89-7 | N-(2-hydroxy-4-nitrophenyl)acetamide |
| NERT-026 | 116496-76-5 | N-(2-ethoxy-4-nitrophenyl)acetamide |
| NERT-027 | 848655-78-7 | N-(4-amino-2-ethoxyphenyl)acetamide |
| NERT-028 | 94-05-3 | ethyl (Z)-2-cyano-3-ethoxyacrylate |
| NERT-029 | 848133-74-4 | (Z)-ethyl 3-((4-acetamido-3-ethoxyphenyl)amino)-2-cyanoacrylate |
| NERT-030 | 848133-75-5 | N-(3-cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide |
Frequently asked questions
What are the approved indications of Neratinib Maleate?
Approved indications include: 乳腺癌.
When does the Neratinib Maleate patent expire?
Based on public sources, the Neratinib Maleate patent expires in 2030.
How many synthesis routes are recorded for Neratinib Maleate?
4 synthesis routes are recorded; the shortest is 3 steps with 0.86 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Neratinib Maleate intermediates?
3 intermediate CAS of Neratinib Maleate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Neratinib Maleate intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24