CAS 942195-80-4

N-(2-(benzyloxy)-4-bromo-6-nitrophenyl)acetamide

Codes：TEGO-002

Application context (from source-drug indications)

胃食管反流病替戈拉生幽门螺杆菌感染替戈拉生十二指肠溃疡替戈拉生短暂性脑缺血发作替戈拉生脑血管疾病替戈拉生缺血性卒中替戈拉生

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
替戈拉生Tegoprazan	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

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替戈拉生原研路线steps: 10total yield: 582 mg

2-(benzyloxy)-4-bromo-6-nitroaniline→N-(2-(benzyloxy)-4-bromo-6-nitrophenyl)acetamide→N-(2-(benzyloxy)-4-cyano-6-nitrophenyl)acetamide→4-(benzyloxy)-2-methyl-1H-benzo[d]imidazole-6-carbonitrile→4-(benzyloxy)-2-methyl-1H-benzo[d]imidazole-6-carboxylic acid→4-(benzyloxy)-N,N,2-trimethyl-1H-benzo[d]imidazole-6-carboxamide→4-(benzyloxy)-N,N,2-trimethyl-1-tosyl-1H-benzo[d]imidazole-6-carboxamide→4-hydroxy-N,N,2-trimethyl-1-tosyl-1H-benzo[d]imidazole-6-carboxamide→5,7-difluorochroman-4-ol→4-((5,7-difluorochroman-4-yl)oxy)-N,N,2-trimethyl-1-tosyl-1H-benzo[d]imidazole-6-carboxamide→4-((5,7-difluorochroman-4-yl)oxy)-N,N,2-trimethyl-1H-benzo[d]imidazole-6-carboxamide

Intermediates available on this site

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Supplier	Product	Price band	MOQ	Lead time	Qualifications
Qualified Partner — East China API Works	(R)-5,7-difluorochroman-4-ol Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	1-benzyl-4-hydroxy-2-methyl-1H-benzo[d]imidazole-6-carboxylic acid Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	7-hydroxy-N,N,2-triMethyl-3-tosyl-3H-benzo[d]iMidazole-5-carboxaMide Pharmaceutical Intermediates	询价	询价	询价	—

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