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甲磺酸奈非那韦
Tier C · 观察 / 贸易Nelfinavir Mesylate
Agouron Pharmaceuticals Llc
原研
1997
首批上市
-
到期年（公开口径）
无销量数据
峰值销售
化学药
类型
靶点：HIV-1 protease
商品名：Viracept
适应症（已批准）：HIV感染
各地区研发/上市状态
美国
批准上市
1997-03-14
欧盟
撤市
中国
申请上市
2002-05-23
日本
批准上市
1998-03-06
合成路线与中间体5 routes
原研路线 × 1优化路线（非专利）× 3工艺路线 × 1
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
原研Route 1步骤 11 · 总收率 54.00 mg
NELF-008163462-16-6NELF-009136465-81-1NELF-010159878-04-3NELF-011159878-05-4NELF-012603-80-5NELF-01362-53-3NELF-0141711-05-3NELF-0156833-23-4NELF-016168899-30-7NELF-00126054-60-4NELF-002108-98-5NELF-003159453-24-4NELF-00429606-02-8NELF-005—NELF-006159878-01-0NELF-007159878-02-1API · 甲磺酸奈非那韦
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| NELF-008 | 163462-16-6 | benzyl ((R)-1-((S)-oxiran-2-yl)-2-(phenylthio)ethyl)carbamate |
| NELF-009 | 136465-81-1 | (3S,4aS,8aS)-N-(tert-butyl)decahydroisoquinoline-3-carboxamide |
| NELF-010 | 159878-04-3 | benzyl ((2R,3R)-4-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-3-hydroxy-1-(phenylthio)butan-2-yl)carbamate |
| NELF-011 | 159878-05-4 | (3S,4aS,8aS)-2-((2R,3R)-3-amino-2-hydroxy-4-(phenylthio)butyl)-N-(tert-butyl)decahydroisoquinoline-3-carboxamide |
| NELF-012 | 603-80-5 | 3-hydroxy-2-methylbenzoic acid |
| NELF-013 | 62-53-3 | aniline |
| NELF-014 | 1711-05-3 | 3-methoxybenzoyl chloride |
| NELF-015 | 6833-23-4 | 3-methoxy-N-phenylbenzamide |
| NELF-016 | 168899-30-7 | 3-methoxy-2-methyl-N-phenylbenzamide |
| NELF-001 | 26054-60-4 | (S)-benzyl (2-oxooxetan-3-yl)carbamate |
| NELF-002 | 108-98-5 | benzenethiol |
| NELF-003 | 159453-24-4 | (R)-2-(((benzyloxy)carbonyl)amino)-3-(phenylthio)propanoic acid |
| NELF-004 | 29606-02-8 | 3-methyl-1-nitro-1-nitrosoguanidine |
| NELF-005 | - | (S)-(2-(((benzyloxy)carbonyl)amino)-3-oxo-2-((phenylthio)methyl)azetidin-1-ium-1-ylidene)amide |
| NELF-006 | 159878-01-0 | (R)-benzyl (4-chloro-3-oxo-1-(phenylthio)butan-2-yl)carbamate |
| NELF-007 | 159878-02-1 | benzyl ((2R,3S)-4-chloro-3-hydroxy-1-(phenylthio)butan-2-yl)carbamate |
优化Route 3步骤 3 · 总收率 /
NELF-009136465-81-1NELF-024307345-97-7NELF-025307345-98-8NELF-026188936-06-3NELF-027188936-07-4API · 甲磺酸奈非那韦
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| NELF-009 | 136465-81-1 | (3S,4aS,8aS)-N-(tert-butyl)decahydroisoquinoline-3-carboxamide |
| NELF-024 | 307345-97-7 | (3S,4R)-4-hydroxytetrahydrofuran-3-aminium 4-methylbenzenesulfonate |
| NELF-025 | 307345-98-8 | 3-(((3S,4R)-4-hydroxytetrahydrofuran-3-yl)carbamoyl)-2-methylphenyl acetate |
| NELF-026 | 188936-06-3 | 3-((S)-4-((R)-2-acetoxy-1-((methylsulfonyl)oxy)ethyl)-4,5-dihydrooxazol-2-yl)-2-methylphenyl acetate |
| NELF-027 | 188936-07-4 | (3S,4aS,8aS)-N-(tert-butyl)-2-((R)-2-hydroxy-2-((S)-2-(3-hydroxy-2-methylphenyl)-4,5-dihydrooxazol-4-yl)ethyl)decahydroisoquinoline-3-carboxamide |
优化Route 4步骤 12 · 总收率 /
NELF-009136465-81-1NELF-027188936-07-4NELF-02887-69-4NELF-02937031-30-4NELF-03073346-74-4NELF-03151064-65-4NELF-03257495-46-2NELF-033231607-42-4NELF-034201402-92-8NELF-035201402-93-9NELF-036231607-41-3NELF-037201402-94-0NELF-038167678-46-8NELF-039201402-95-1API · 甲磺酸奈非那韦
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| NELF-009 | 136465-81-1 | (3S,4aS,8aS)-N-(tert-butyl)decahydroisoquinoline-3-carboxamide |
| NELF-027 | 188936-07-4 | (3S,4aS,8aS)-N-(tert-butyl)-2-((R)-2-hydroxy-2-((S)-2-(3-hydroxy-2-methylphenyl)-4,5-dihydrooxazol-4-yl)ethyl)decahydroisoquinoline-3-carboxamide |
| NELF-028 | 87-69-4 | (2R,3R)-2,3-dihydroxysuccinic acid |
| NELF-029 | 37031-30-4 | (4S,5S)-dimethyl 2,2-dimethyl-1,3-dioxolane-4,5-dicarboxylate |
| NELF-030 | 73346-74-4 | ((4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)dimethanol |
| NELF-031 | 51064-65-4 | ((4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene) bis(4-methylbenzenesulfonate) |
| NELF-032 | 57495-46-2 | (2S,3S)-2,3-dihydroxybutane-1,4-diyl bis(4-methylbenzenesulfonate) |
| NELF-033 | 231607-42-4 | ((4R,5R)-2-oxido-1,3,2-dioxathiolane-4,5-diyl)bis(methylene) bis(4-methylbenzenesulfonate) |
| NELF-034 | 201402-92-8 | ((4R,5R)-2,2-dioxido-1,3,2-dioxathiolane-4,5-diyl)bis(methylene) bis(4-methylbenzenesulfonate) |
| NELF-035 | 201402-93-9 | sodium (2S,3S)-3-azido-1,4-bis(tosyloxy)butan-2-yl sulfate |
| NELF-036 | 231607-41-3 | (2S,3S)-2-azido-3-hydroxybutane-1,4-diyl bis(4-methylbenzenesulfonate) |
| NELF-037 | 201402-94-0 | (2S,3S)-3-hydroxy-1,4-bis(tosyloxy)butan-2-aminium chloride |
| NELF-038 | 167678-46-8 | 3-(chlorocarbonyl)-2-methylphenyl acetate |
| NELF-039 | 201402-95-1 | 3-((S)-4-((S)-1-hydroxy-2-(tosyloxy)ethyl)-4,5-dihydrooxazol-2-yl)-2-methylphenyl acetate |
优化Route 5步骤 3 · 总收率 /
NELF-009136465-81-1NELF-040767341-33-3NELF-041767341-29-7NELF-042168899-58-9NELF-043767341-31-1NELF-044767341-27-5API · 甲磺酸奈非那韦
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| NELF-009 | 136465-81-1 | (3S,4aS,8aS)-N-(tert-butyl)decahydroisoquinoline-3-carboxamide |
| NELF-040 | 767341-33-3 | (1R)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-(phenylsulfinyl)ethanamine |
| NELF-041 | 767341-29-7 | 1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-(phenylthio)ethanamine |
| NELF-042 | 168899-58-9 | 3-acetoxy-2-methylbenzoic acid |
| NELF-043 | 767341-31-1 | 3-(((R)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-(phenylthio)ethyl)carbamoyl)-2-methylphenyl acetate |
| NELF-044 | 767341-27-5 | 3-(((2R,3S)-3,4-dihydroxy-1-(phenylthio)butan-2-yl)carbamoyl)-2-methylphenyl acetate |
工艺Route 2步骤 7 · 总收率 1.10 kg
NELF-009136465-81-1NELF-010159878-04-3NELF-017188923-19-5NELF-018265135-66-8NELF-019188923-23-1NELF-020188923-24-2NELF-021188923-25-3NELF-0221026343-65-6NELF-023188923-26-4API · 甲磺酸奈非那韦
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| NELF-009 | 136465-81-1 | (3S,4aS,8aS)-N-(tert-butyl)decahydroisoquinoline-3-carboxamide |
| NELF-010 | 159878-04-3 | benzyl ((2R,3R)-4-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-3-hydroxy-1-(phenylthio)butan-2-yl)carbamate |
| NELF-017 | 188923-19-5 | (5R,6S)-2,2-dimethyl-6-(((R)-1-phenylethyl)amino)-1,3-dioxepan-5-ol |
| NELF-018 | 265135-66-8 | (S)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-hydroxyethanaminium benzoate |
| NELF-019 | 188923-23-1 | benzyl ((S)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-hydroxyethyl)carbamate |
| NELF-020 | 188923-24-2 | benzyl ((R)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-(phenylthio)ethyl)carbamate |
| NELF-021 | 188923-25-3 | benzyl ((2R,3R)-3,4-dihydroxy-1-(phenylthio)butan-2-yl)carbamate |
| NELF-022 | 1026343-65-6 | (2R,3R)-3-(((benzyloxy)carbonyl)amino)-2-hydroxy-4-(phenylthio)butyl 4-nitrobenzoate |
| NELF-023 | 188923-26-4 | (2R,3R)-3-(((benzyloxy)carbonyl)amino)-2-((methylsulfonyl)oxy)-4-(phenylthio)butyl 4-nitrobenzoate |
常见问题（FAQ）
甲磺酸奈非那韦的适应症有哪些？
已批准的适应症包括：HIV感染。
甲磺酸奈非那韦的专利什么时候到期？
甲磺酸奈非那韦的专利到期年暂无公开口径，本页会在数据管道核实后更新。
甲磺酸奈非那韦有几条合成路线？
本站收录 5 条合成路线，最短路线 3 步、总收率 /。每条路线的中间体均带登记编号与 CAS 号。
甲磺酸奈非那韦的关键中间体在哪里可以采购？
甲磺酸奈非那韦路线中的中间体均已建立 CAS 档案，可直接按 CAS 发起询价，需求会进入供应网络撮合池。
如何获取甲磺酸奈非那韦中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-09-27