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CAS 159878-04-3
benzyl ((2R,3R)-4-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-3-hydroxy-1-(phenylthio)butan-2-yl)carbamate
登记编号：NELF-010
应用背景（按来源药适应症）
HIV感染甲磺酸奈非那韦骨髓纤维化甲磺酸奈非那韦子宫颈功能不全甲磺酸奈非那韦系统性红斑狼疮甲磺酸奈非那韦非小细胞肺癌甲磺酸奈非那韦巨细胞病毒性视网膜炎甲磺酸奈非那韦
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 甲磺酸奈非那韦Nelfinavir Mesylate | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
benzyl ((R)-1-((S)-oxiran-2-yl)-2-(phenylthio)ethyl)carbamate→(3S,4aS,8aS)-N-(tert-butyl)decahydroisoquinoline-3-carboxamide→benzyl ((2R,3R)-4-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-3-hydroxy-1-(phenylthio)butan-2-yl)carbamate→(3S,4aS,8aS)-2-((2R,3R)-3-amino-2-hydroxy-4-(phenylthio)butyl)-N-(tert-butyl)decahydroisoquinoline-3-carboxamide→3-hydroxy-2-methylbenzoic acid→aniline→3-methoxybenzoyl chloride→3-methoxy-N-phenylbenzamide→3-methoxy-2-methyl-N-phenylbenzamide→(S)-benzyl (2-oxooxetan-3-yl)carbamate→benzenethiol→(R)-2-(((benzyloxy)carbonyl)amino)-3-(phenylthio)propanoic acid→3-methyl-1-nitro-1-nitrosoguanidine→(S)-(2-(((benzyloxy)carbonyl)amino)-3-oxo-2-((phenylthio)methyl)azetidin-1-ium-1-ylidene)amide→(R)-benzyl (4-chloro-3-oxo-1-(phenylthio)butan-2-yl)carbamate→benzyl ((2R,3S)-4-chloro-3-hydroxy-1-(phenylthio)butan-2-yl)carbamate
(3S,4aS,8aS)-N-(tert-butyl)decahydroisoquinoline-3-carboxamide→benzyl ((2R,3R)-4-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-3-hydroxy-1-(phenylthio)butan-2-yl)carbamate→(5R,6S)-2,2-dimethyl-6-(((R)-1-phenylethyl)amino)-1,3-dioxepan-5-ol→(S)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-hydroxyethanaminium benzoate→benzyl ((S)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-hydroxyethyl)carbamate→benzyl ((R)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-(phenylthio)ethyl)carbamate→benzyl ((2R,3R)-3,4-dihydroxy-1-(phenylthio)butan-2-yl)carbamate→(2R,3R)-3-(((benzyloxy)carbonyl)amino)-2-hydroxy-4-(phenylthio)butyl 4-nitrobenzoate→(2R,3R)-3-(((benzyloxy)carbonyl)amino)-2-((methylsulfonyl)oxy)-4-(phenylthio)butyl 4-nitrobenzoate
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