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CAS 136465-81-1
(3S,4aS,8aS)-N-(tert-butyl)decahydroisoquinoline-3-carboxamide
登记编号：NELF-009
应用背景（按来源药适应症）
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来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 甲磺酸奈非那韦Nelfinavir Mesylate | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
benzyl ((R)-1-((S)-oxiran-2-yl)-2-(phenylthio)ethyl)carbamate→(3S,4aS,8aS)-N-(tert-butyl)decahydroisoquinoline-3-carboxamide→benzyl ((2R,3R)-4-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-3-hydroxy-1-(phenylthio)butan-2-yl)carbamate→(3S,4aS,8aS)-2-((2R,3R)-3-amino-2-hydroxy-4-(phenylthio)butyl)-N-(tert-butyl)decahydroisoquinoline-3-carboxamide→3-hydroxy-2-methylbenzoic acid→aniline→3-methoxybenzoyl chloride→3-methoxy-N-phenylbenzamide→3-methoxy-2-methyl-N-phenylbenzamide→(S)-benzyl (2-oxooxetan-3-yl)carbamate→benzenethiol→(R)-2-(((benzyloxy)carbonyl)amino)-3-(phenylthio)propanoic acid→3-methyl-1-nitro-1-nitrosoguanidine→(S)-(2-(((benzyloxy)carbonyl)amino)-3-oxo-2-((phenylthio)methyl)azetidin-1-ium-1-ylidene)amide→(R)-benzyl (4-chloro-3-oxo-1-(phenylthio)butan-2-yl)carbamate→benzyl ((2R,3S)-4-chloro-3-hydroxy-1-(phenylthio)butan-2-yl)carbamate
(3S,4aS,8aS)-N-(tert-butyl)decahydroisoquinoline-3-carboxamide→benzyl ((2R,3R)-4-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-3-hydroxy-1-(phenylthio)butan-2-yl)carbamate→(5R,6S)-2,2-dimethyl-6-(((R)-1-phenylethyl)amino)-1,3-dioxepan-5-ol→(S)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-hydroxyethanaminium benzoate→benzyl ((S)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-hydroxyethyl)carbamate→benzyl ((R)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-(phenylthio)ethyl)carbamate→benzyl ((2R,3R)-3,4-dihydroxy-1-(phenylthio)butan-2-yl)carbamate→(2R,3R)-3-(((benzyloxy)carbonyl)amino)-2-hydroxy-4-(phenylthio)butyl 4-nitrobenzoate→(2R,3R)-3-(((benzyloxy)carbonyl)amino)-2-((methylsulfonyl)oxy)-4-(phenylthio)butyl 4-nitrobenzoate
(3S,4aS,8aS)-N-(tert-butyl)decahydroisoquinoline-3-carboxamide→(3S,4R)-4-hydroxytetrahydrofuran-3-aminium 4-methylbenzenesulfonate→3-(((3S,4R)-4-hydroxytetrahydrofuran-3-yl)carbamoyl)-2-methylphenyl acetate→3-((S)-4-((R)-2-acetoxy-1-((methylsulfonyl)oxy)ethyl)-4,5-dihydrooxazol-2-yl)-2-methylphenyl acetate→(3S,4aS,8aS)-N-(tert-butyl)-2-((R)-2-hydroxy-2-((S)-2-(3-hydroxy-2-methylphenyl)-4,5-dihydrooxazol-4-yl)ethyl)decahydroisoquinoline-3-carboxamide
(3S,4aS,8aS)-N-(tert-butyl)decahydroisoquinoline-3-carboxamide→(3S,4aS,8aS)-N-(tert-butyl)-2-((R)-2-hydroxy-2-((S)-2-(3-hydroxy-2-methylphenyl)-4,5-dihydrooxazol-4-yl)ethyl)decahydroisoquinoline-3-carboxamide→(2R,3R)-2,3-dihydroxysuccinic acid→(4S,5S)-dimethyl 2,2-dimethyl-1,3-dioxolane-4,5-dicarboxylate→((4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)dimethanol→((4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene) bis(4-methylbenzenesulfonate)→(2S,3S)-2,3-dihydroxybutane-1,4-diyl bis(4-methylbenzenesulfonate)→((4R,5R)-2-oxido-1,3,2-dioxathiolane-4,5-diyl)bis(methylene) bis(4-methylbenzenesulfonate)→((4R,5R)-2,2-dioxido-1,3,2-dioxathiolane-4,5-diyl)bis(methylene) bis(4-methylbenzenesulfonate)→sodium (2S,3S)-3-azido-1,4-bis(tosyloxy)butan-2-yl sulfate→(2S,3S)-2-azido-3-hydroxybutane-1,4-diyl bis(4-methylbenzenesulfonate)→(2S,3S)-3-hydroxy-1,4-bis(tosyloxy)butan-2-aminium chloride→3-(chlorocarbonyl)-2-methylphenyl acetate→3-((S)-4-((S)-1-hydroxy-2-(tosyloxy)ethyl)-4,5-dihydrooxazol-2-yl)-2-methylphenyl acetate
(3S,4aS,8aS)-N-(tert-butyl)decahydroisoquinoline-3-carboxamide→(1R)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-(phenylsulfinyl)ethanamine→1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-(phenylthio)ethanamine→3-acetoxy-2-methylbenzoic acid→3-(((R)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-(phenylthio)ethyl)carbamoyl)-2-methylphenyl acetate→3-(((2R,3S)-3,4-dihydroxy-1-(phenylthio)butan-2-yl)carbamoyl)-2-methylphenyl acetate
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