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CAS 1441769-24-9
3-amino-5-chloro-1-methylpyridin-2(1H)-one
登记编号：HDM-201-008
应用背景（按来源药适应症）
肉瘤Siremadlin血液肿瘤Siremadlin肝功能衰退Siremadlin急性髓细胞样白血病Siremadlin结直肠癌Siremadlin转移癌Siremadlin
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| Siremadlin | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(S)-5-(5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-1-isopropyl-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one→ethyl 2-cyanoacetate→1,1-diethoxy-N,N-dimethylmethanamine→ethyl (E)-2-cyano-3-(dimethylamino)acrylate→ethyl 1-isopropyl-1H-imidazole-4-carboxylate→ethyl 2-bromo-1-isopropyl-1H-imidazole-4-carboxylate→4-chlorobenzaldehyde→ethyl 2-bromo-5-((4-chlorophenyl)(hydroxy)methyl)-1-isopropyl-1H-imidazole-4-carboxylate→3-amino-5-chloro-1-methylpyridin-2(1H)-one→ethyl 2-bromo-5-(((5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)amino)(4-chlorophenyl)methyl)-1-isopropyl-1H-imidazole-4-carboxylate→2-bromo-5-(((5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)amino)(4-chlorophenyl)methyl)-1-isopropyl-1H-imidazole-4-carboxylic acid→2-bromo-5-(5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-6-(4-chlorophenyl)-1-isopropyl-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one→(2,4-dimethoxypyrimidin-5-yl)boronic acid→5-(5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-1-isopropyl-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one→5-chloro-3-nitropyridin-2-ol→5-chloro-1-methyl-3-nitropyridin-2(1H)-one
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