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CAS 105-56-6
ethyl 2-cyanoacetate2-Cyanoacetic acid ethyl ester
登记编号：TOFA-009、AVAN-034、VONO-003、ETRA-015、Cefoselis Sulfate-012
应用背景（按来源药适应症）
强直性脊柱炎枸橼酸托法替布幼年型类风湿性关节炎枸橼酸托法替布溃疡性结肠炎枸橼酸托法替布银屑病关节炎枸橼酸托法替布类风湿关节炎枸橼酸托法替布勃起功能障碍阿伐那非消化性溃疡出血醋酸伏诺拉生幽门螺杆菌感染富马酸伏诺拉生食管炎富马酸伏诺拉生胃食管反流病富马酸伏诺拉生胃灼痛富马酸伏诺拉生消化性食管炎富马酸伏诺拉生螺杆菌感染富马酸伏诺拉生HIV感染依曲韦林弗里德赖希共济失调依曲韦林炎性疾病依曲韦林胰岛素抵抗依曲韦林细菌感染硫酸头孢噻利
来源药（使用该中间体的合成路线）
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
1-benzyl-N,4-dimethylpiperidin-3-amine→4-chloro-7H-pyrrolo[2,3-d]pyrimidine→N-(1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine→N-methyl-N-(4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine→4-chloro-7-(methylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine→N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7-(methylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine→ethyl 2-cyanoacetate
(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine hemi((2R,3R)-2,3-bis((4-methylbenzoyl)oxy)succinate)→2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine→N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-2-chloro-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine→1-benzyl-N,4-dimethylpiperidin-3-amine→N-methyl-N-(4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine→ethyl 2-cyanoacetate→methyl (4-methylpyridin-3-yl)carbamate→1-benzyl-3-((methoxycarbonyl)amino)-4-methylpyridin-1-ium chloride→methyl (1-benzyl-4-methyl-1,2,5,6-tetrahydropyridin-3-yl)carbamate
(S)-pyrrolidin-2-ylmethanol→ethyl (S)-4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidine-5-carboxylate→pyrimidin-2-ylmethanamine→ethyl 2-cyanoacetate→urea→ethyl (E)-2-cyano-3-ureidoacrylate→ethyl 6-amino-2-oxo-1,2-dihydropyrimidine-5-carboxylate→2-chloro-4-(chloromethyl)-1-methoxybenzene→ethyl 6-((3-chloro-4-methoxybenzyl)amino)-2-oxo-1,2-dihydropyrimidine-5-carboxylate
1-(2-fluorophenyl)ethanone→2-bromo-1-(2-fluorophenyl)ethanone→ethyl 2-cyanoacetate→ethyl 2-cyano-4-(2-fluorophenyl)-4-oxobutanoate→ethyl 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate→ethyl 5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate→(5-(2-fluorophenyl)-1H-pyrrol-3-yl)methanol→5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde→pyridine-3-sulfonyl chloride hydrochloride→5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde→fumaric acid→pyridine-3-sulfonic acid
1-(2-fluorophenyl)ethanone→2-bromo-1-(2-fluorophenyl)ethanone→ethyl 2-cyanoacetate→ethyl 2-cyano-4-(2-fluorophenyl)-4-oxobutanoate→ethyl 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate→ethyl 5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate→(5-(2-fluorophenyl)-1H-pyrrol-3-yl)methanol→5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde→pyridine-3-sulfonyl chloride hydrochloride→5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde→fumaric acid→pyridine-3-sulfonic acid
4-hydroxy-3,5-dimethylbenzonitrile→1-(4-cyanophenyl)guanidine hydrochloride→ethyl 2-cyanoacetate→4-((4-amino-6-hydroxypyrimidin-2-yl)amino)benzonitrile→4-((4-amino-6-chloropyrimidin-2-yl)amino)benzonitrile→N-(6-chloro-2-((4-cyanophenyl)amino)pyrimidin-4-yl)benzamide→N-(5-bromo-6-chloro-2-((4-cyanophenyl)amino)pyrimidin-4-yl)benzamide→N-(5-bromo-6-(4-cyano-2,6-dimethylphenoxy)-2-((4-cyanophenyl)amino)pyrimidin-4-yl)benzamide
2-(5-Amino-1H-pyrazol-1-yl)ethan-1-ol→N,N-Dimethylformamide→2-Cyanoacetic acid methyl ester→2-Cyanoacetic acid ethyl ester→Propyl cyanoacetate→Butyl cyanoacetate→Methyl 2-cyano-3-(dimethylamino)prop-2-enoate→Ethyl 2-cyano-3-(dimethylamino)prop-2-enoate→Propyl 2-cyano-3-(dimethylamino)prop-2-enoate→Butyl 2-cyano-3-(dimethylamino)prop-2-enoate→2-Hydrazinoethanol→Methyl 5-amino-1-(2-hydroxyethyl)-1H-pyrazole-4-carboxylate→Ethyl 5-amino-1-(2-hydroxyethyl)-1H-pyrazole-4-carboxylate→Propyl 5-amino-1-(2-hydroxyethyl)-1H-pyrazole-4-carboxylate→Butyl 5-amino-1-(2-hydroxyethyl)-1H-pyrazole-4-carboxylate→5-Amino-1-(2-hydroxyethyl)-1H-pyrazole-4-carboxylic acid→Hex-3-enedinitrile→But-3-enenitrile→3-Oxopropanenitrile→3,3-Dimethoxypropanenitrile→3-[2-(2-Hydroxyethyl)hydrazinylidene]propanenitrile
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 |
|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | （3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine HCL Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | 4-Chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | 1-benzyl-4-methylpiperidin-3-one Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | 5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | 5-(2-fluorophenyl)-1H-pyrrole-3-carboxylic acid methyl ester Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | 2-[2-(2-Fluorophenyl)-2-oxoethyl]propanedinitrile Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | pyridine-3-sulfonyl chloride Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | 1H-Pyrrole-3-carboxylic acid, 5-(2-fluorophenyl)-, ethyl ester Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | Vonoprazan Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | 3-Pyridinesulfonyl chloride Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | 5-(2-fluorophenyl)-1H-Pyrrole-3-carboxaldehyde Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。