← 返回专利悬崖列表
CAS 145783-14-8
4,6-dichloro-5-nitro-2-(propylthio)pyrimidine
登记编号：TICA-001
应用背景（按来源药适应症）
中风替格瑞洛急性冠脉综合征替格瑞洛心肌梗塞替格瑞洛外周血管疾病替格瑞洛
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 替格瑞洛Ticagrelor | Tier B · 提前布局 | 2029 |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
4,6-dichloro-5-nitro-2-(propylthio)pyrimidine→(3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-ol→(3aR,4S,6R,6aS)-6-((6-chloro-5-nitro-2-(propylthio)pyrimidin-4-yl)amino)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-ol→(3aR,4S,6R,6aS)-6-((5-amino-6-chloro-2-(propylthio)pyrimidin-4-yl)amino)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-ol→(3aR,4S,6R,6aS)-6-(7-chloro-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-ol→(3aR,4S,6R,6aS)-6-(7-amino-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-ol→methyl 2-(((trifluoromethyl)sulfonyl)oxy)acetate→methyl 2-(((3aR,4S,6R,6aS)-6-(7-amino-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate→methyl 2-(((3aR,4S,6R,6aS)-6-(7-bromo-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate→(1R,2S)-2-(3,4-difluorophenyl)cyclopropan-1-amine→methyl 2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate→potassium sodium (2R,3R)-2,3-dihydroxysuccinate→2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethan-1-ol→(1R,4S)-4-hydroxycyclopent-2-en-1-yl acetate→TICA-015→TICA-016→4-methylmorpholine 4-oxide→TICA-018→2,2-dimethoxypropane
4,6-dichloro-5-nitro-2-(propylthio)pyrimidine→(1R,2S)-2-(3,4-difluorophenyl)cyclopropan-1-amine→ethyl 2-(((3aR,4S,6R,6aS)-6-(((benzyloxy)carbonyl)amino)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate→ethyl 2-(((1S,2S,3S,4R)-4-(((benzyloxy)carbonyl)amino)-2,3-dihydroxycyclopentyl)oxy)acetate→ethyl 2-(((3aR,4S,6R,6aS)-6-(((benzyloxy)carbonyl)amino)-2-oxotetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate→benzyl ((3aS,4R,6S,6aR)-6-(2-hydroxyethoxy)-2-oxotetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)carbamate→(3aS,4R,6S,6aR)-4-amino-6-(2-hydroxyethoxy)tetrahydro-4H-cyclopenta[d][1,3]dioxol-2-one→(3aS,4R,6S,6aR)-4-((6-chloro-5-nitro-2-(propylthio)pyrimidin-4-yl)amino)-6-(2-hydroxyethoxy)tetrahydro-4H-cyclopenta[d][1,3]dioxol-2-one→(3aS,4R,6S,6aR)-4-((5-amino-6-chloro-2-(propylthio)pyrimidin-4-yl)amino)-6-(2-hydroxyethoxy)tetrahydro-4H-cyclopenta[d][1,3]dioxol-2-one→(3aS,4R,6S,6aR)-4-(7-chloro-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-6-(2-hydroxyethoxy)tetrahydro-4H-cyclopenta[d][1,3]dioxol-2-one→(3aS,4R,6S,6aR)-4-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-6-(2-hydroxyethoxy)tetrahydro-4H-cyclopenta[d][1,3]dioxol-2-one
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。