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CAS 187960-87-8
2-[(1S,5S,6S,7S,8S,12S)-7,11,14,14-tetramethyl-3,9-dioxo-8-[(triethylsilyl)oxy]-12-[(triisopropylsilyl)oxy]-2,4-dioxatricyclo[8.3.1.0(1,5)]tetradec-10-en-6-yl]prop-2-enal
登记编号：(XVII)101438-31-a,(XVII)101438-31-b
应用背景（按来源药适应症）
乳腺癌Paclitaxel/Encequidar mesylate腺癌Paclitaxel/Encequidar mesylate血管肉瘤Paclitaxel/Encequidar mesylate实体瘤Paclitaxel/Encequidar mesylate
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| Paclitaxel/Encequidar mesylatePaclitaxel/Encequidar mesylate | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
4,6,6-trimethylbicyclo[3.1.1]hept-3-en-2-one→1-Bromo-3-methyl-2-butene→2-{2,6,6-trimethyl-4-oxobicyclo[3.1.1]hept-2-en-3-yl}acetaldehyde→2-{2,6,6-trimethyl-7-oxobicyclo[3.1.1]hept-2-en-1-yl}acetaldehyde→ethyl (2S,6R)-2,6-dihydroxy-4,10,11,11-tetramethyl-3-oxotricyclo[5.3.1.0(1,6)]undeca-4,9-diene-5-carboxylate→(Ethoxycarbonyl)acetylene→ethyl 5-{2,6,6-trimethyl-7-oxobicyclo[3.1.1]hept-2-en-1-yl}-4-[(trimethylsilyl)oxy]pent-2-ynoate→ethyl (6R)-3,6-dihydroxy-4,10,11,11-tetramethyltricyclo[5.3.1.0(1,6)]undeca-4,9-diene-5-carboxylate→ethyl (6R)-6-hydroxy-4,10,11,11-tetramethyl-3-oxotricyclo[5.3.1.0(1,6)]undeca-4,9-diene-5-carboxylate→(2S,3S,6S)-5-(hydroxymethyl)-4,10,11,11-tetramethyltricyclo[5.3.1.0(1,6)]undeca-4,9-diene-2,3,6-triol→(2S,6S,9S)-8-{[(tert-butyldimethylsilyl)oxy]methyl}-4,4,7,13,14,14-hexamethyl-3,5-dioxatetracyclo[8.3.1.0(1,9).0(2,6)]tetradeca-7,12-dien-9-ol→(2S,6S,7Z,12S)-8-{[(tert-butyldimethylsilyl)oxy]methyl}-4,4,7,13,14,14-hexamethyl-12-{[tris(propan-2-yl)silyl]oxy}-3,5-dioxatricyclo[8.3.1.0(2,6)]tetradeca-1(13),7-dien-9-one→(2S,6S,7Z,9S,10S,12S)-8-(hydroxymethyl)-4,4,7,13,14,14-hexamethyl-12-[(triisopropylsilyl)oxy]-3,5-dioxatricyclo[8.3.1.0(2,6)]tetradeca-1(13),7-diene-9,10-diol→(1S,5S,6S,7S,8S,12S,15S)-7,10,10,14,17,17-hexamethyl-6-{[(trimethylsilyl)oxy]methyl}-15-{[tris(propan-2-yl)silyl]oxy}-2,4,9,11-tetraoxatetracyclo[11.3.1.0(1,5).0(8,12)]heptadec-13-en-3-one→(1S,5S,6R,7S,8S,12S,15S)-7,10,10,14,17,17-hexamethyl-3-oxo-15-[(triisopropylsilyl)oxy]-2,4,9,11-tetraoxatetracyclo[11.3.1.0(1,5).0(8,12)]heptadec-13-ene-6-carbaldehyde→2-[(1S,5S,6R,7S,8S,9S,12S)-8,9-dihydroxy-7,11,14,14-tetramethyl-3-oxo-12-{[tris(propan-2-yl)silyl]oxy}-2,4-dioxatricyclo[8.3.1.0(1,5)]tetradec-10-en-6-yl]acetaldehyde→2-[(1S,5S,6S,7S,8S,12S)-7,11,14,14-tetramethyl-3,9-dioxo-8-[(triethylsilyl)oxy]-12-[(triisopropylsilyl)oxy]-2,4-dioxatricyclo[8.3.1.0(1,5)]tetradec-10-en-6-yl]prop-2-enal
(1S,2S,3S,4S,5S,9S)-5-(acetyloxy)-3-[(3R)-3-[(benzyloxy)methoxy]hexa-1,5-dien-2-yl]-1-hydroxy-4,8,11,11-tetramethyl-6-oxo-9-[(triisopropylsilyl)oxy]bicyclo[5.3.1]undec-7-en-2-yl benzoate→2-[(1S,5S,6S,7S,8S,12S)-7,11,14,14-tetramethyl-3,9-dioxo-8-[(triethylsilyl)oxy]-12-[(triisopropylsilyl)oxy]-2,4-dioxatricyclo[8.3.1.0(1,5)]tetradec-10-en-6-yl]prop-2-enal→(1S,5S,6S,7S,8S,12S)-6-[(3R)-3-[(benzyloxy)methoxy]hexa-1,5-dien-2-yl]-7,11,14,14-tetramethyl-8-[(triethylsilyl)oxy]-12-{[tris(propan-2-yl)silyl]oxy}-2,4-dioxatricyclo[8.3.1.0(1,5)]tetradec-10-ene-3,9-dione→1,3,4,6,7,8-Hexahydro-2H-pyrimido[1,2-a]pyrimidine→(1S,2S,3S,4S,6R,9S)-6-(acetyloxy)-3-[(3R)-3-[(benzyloxy)methoxy]hexa-1,5-dien-2-yl]-1-hydroxy-4,8,11,11-tetramethyl-5-oxo-9-{[tris(propan-2-yl)silyl]oxy}bicyclo[5.3.1]undec-7-en-2-yl benzoate→(1S,2S,3S,4S,6R,9S)-6-(acetyloxy)-3-[(3R)-3-[(benzyloxy)methoxy]-5-oxopent-1-en-2-yl]-1-hydroxy-4,8,11,11-tetramethyl-5-oxo-9-{[tris(propan-2-yl)silyl]oxy}bicyclo[5.3.1]undec-7-en-2-yl benzoate→(1S,2S,3R,5R,7S,8S,10R,13S)-10-(acetyloxy)-5-[(benzyloxy)methoxy]-1,7-dihydroxy-8,12,15,15-tetramethyl-4-methylidene-9-oxo-13-[(triisopropylsilyl)oxy]tricyclo[9.3.1.0(3,8)]pentadec-11-en-2-yl benzoate→(1S,2S,3R,5R,7S,8S,10R,13S)-10-(acetyloxy)-5-[(benzyloxy)methoxy]-1-hydroxy-8,12,15,15-tetramethyl-4-methylidene-9-oxo-7-{[(2,2,2-trichloroethoxy)carbonyl]oxy}-13-{[tris(propan-2-yl)silyl]oxy}tricyclo[9.3.1.0(3,8)]pentadec-11-en-2-yl benzoate→(1S,5S,6R,7S,10R,12S,13S,15R,18S)-15-(acetyloxy)-13,17,20,20-tetramethyl-3,14-dioxo-12-{[(2,2,2-trichloroethoxy)carbonyl]oxy}-18-[(triisopropylsilyl)oxy]-2,4,9-trioxapentacyclo[14.3.1.0(1,5).0(6,13).0(7,10)]icos-16-en-7-yl acetate→(1S,2S,3R,5R,7S,8S,10R,13S)-10-(acetyloxy)-1,5-dihydroxy-8,12,15,15-tetramethyl-4-methylidene-9-oxo-7-{[(2,2,2-trichloroethoxy)carbonyl]oxy}-13-[(triisopropylsilyl)oxy]tricyclo[9.3.1.0(3,8)]pentadec-11-en-2-yl benzoate→(1S,2S,3R,5R,7S,8S,10R,13S)-10-(acetyloxy)-1-hydroxy-5-(methanesulfonyloxy)-8,12,15,15-tetramethyl-4-methylidene-9-oxo-7-{[(2,2,2-trichloroethoxy)carbonyl]oxy}-13-{[tris(propan-2-yl)silyl]oxy}tricyclo[9.3.1.0(3,8)]pentadec-11-en-2-yl benzoate→(1S,2S,3S,5S,7S,8S,10R,13S)-10-(acetyloxy)-5-bromo-1-hydroxy-8,12,15,15-tetramethyl-4-methylidene-9-oxo-7-{[(2,2,2-trichloroethoxy)carbonyl]oxy}-13-[(triisopropylsilyl)oxy]tricyclo[9.3.1.0(3,8)]pentadec-11-en-2-yl benzoate→(1S,5S,6R,7S,8S,10S,11S,13R,16S)-8-bromo-7-hydroxy-7-(hydroxymethyl)-11,15,18,18-tetramethyl-3,12-dioxo-10-{[(2,2,2-trichloroethoxy)carbonyl]oxy}-16-{[tris(propan-2-yl)silyl]oxy}-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-en-13-yl acetate→Allyl(bromo)magnesium
本站可供应的对应中间体
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