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CAS 623-47-2
ethyl propiolate(Ethoxycarbonyl)acetylene
登记编号：SELP-007、(III)169995-11-a,(III)169995-11-b、(II)169995-17-a、(II)169995-22-a
应用背景（按来源药适应症）
实体瘤塞普替尼甲状腺髓样癌塞普替尼非小细胞肺癌塞普替尼甲状腺瘤塞普替尼避孕屈螺酮口腔炎，口疮屈螺酮经前焦虑性障碍屈螺酮经前期综合征屈螺酮痛经屈螺酮抑郁屈螺酮
来源药（使用该中间体的合成路线）
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
4-(6-fluoropyridin-3-yl)-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile→tert-butyl 3,6-diazabicyclo[3.1.1]heptane-6-carboxylate→tert-butyl 3-(5-(3-cyano-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridin-4-yl)pyridin-2-yl)-3,6-diazabicyclo[3.1.1]heptane-6-carboxylate→4-(6-(3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile→6-methoxynicotinaldehyde→tert-butyl hydroxycarbamate→2,4,6-trimethylbenzenesulfonyl chloride→tert-butyl ((mesitylsulfonyl)oxy)carbamate→O-(mesitylsulfonyl)hydroxylamine→3-bromo-5-methoxypyridine→1-amino-3-bromo-5-methoxypyridin-1-ium 2,4,6-trimethylbenzenesulfonate→ethyl propiolate→ethyl 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carboxylate→ethyl 4-bromo-6-methoxypyrazolo[1,5-a]pyridine-3-carboxylate→4-bromo-6-methoxypyrazolo[1,5-a]pyridine→4-bromo-6-methoxypyrazolo[1,5-a]pyridine-3-carbaldehyde→(E)-4-bromo-6-methoxypyrazolo[1,5-a]pyridine-3-carbaldehyde oxime→4-bromo-6-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile→4-bromo-6-hydroxypyrazolo[1,5-a]pyridine-3-carbonitrile→2,2-dimethyloxirane→4-bromo-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile→2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
(1aR,1bR,3S,5aR,5bS,7aS,8aS,9aS,9bS,9cR,9dR)-1b,3-Dihydroxy-5a,7a-dimethylperhydrocyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthren-8-one→3beta-[tert-Butyl(dimethyl)silyloxy]-5beta-hydroxy-6beta,7beta:15beta,16beta-dimethyleneandrostan-17-one→(Ethoxycarbonyl)acetylene→3-[3beta-[tert-Butyl(dimethyl)silyloxy]-5beta,17beta-dihydroxy-6beta,7beta:15beta,16beta-dimethyleneandrostan-17-yl]-2-propynoic acid ethyl ester→3-[3beta,5beta,17beta-Trihydroxy-6beta,7beta:15beta,16beta-dimethyleneandrostan-17-yl]-2-propynoic acid ethyl ester→3-[5beta,17beta-Dihydroxy-6beta,7beta:15beta,16beta-dimethylene-3-oxoandrostan-17-yl]-2-propynoic acid ethyl ester→3-[17beta-Hydroxy-6beta,7beta:15beta,16beta-dimethylene-3-oxoandrost-4-en-17-yl]-2-propynoic acid ethyl ester→3-[17beta-Hydroxy-6beta,7beta:15beta,16beta-dimethylene-3-oxoandrost-4-en-17-yl]-2-propynoic acid
(1aR,1bR,3S,5aR,5bS,7aS,8aS,9aS,9bS,9cR,9dR)-1b,3-Dihydroxy-5a,7a-dimethylperhydrocyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthren-8-one→(Ethoxycarbonyl)acetylene→3-[3beta,5beta,17beta-Trihydroxy-6beta,7beta:15beta,16beta-dimethyleneandrostan-17-yl]-2-propynoic acid ethyl ester→5beta-Hydroxy-6beta,7beta:15beta,16beta-dimethylene-3beta-(trimethylsilyloxy)androstan-17-one→3-[5beta,17beta-Dihydroxy-6beta,7beta:15beta,16beta-dimethylene-3beta-(trimethylsilyloxy)androstan-17-yl]-2-propynoic acid ethyl ester
(1aR,1bR,3S,5aR,5bS,7aS,8aS,9aS,9bS,9cR,9dR)-1b,3-Dihydroxy-5a,7a-dimethylperhydrocyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthren-8-one→(Ethoxycarbonyl)acetylene→3-(3beta,5beta,17alpha-Trihydroxy-6beta,7beta:15beta,16beta-dimethyleneandrostan-17-yl)-2-propynoic acid ethyl ester→3-(3beta,5beta,17alpha-dihydroxy-6beta,7beta:15beta,16beta-dimethyleneandrostan-17-yl)propionic acid ethyl ester→3-(5beta,17alpha-Dihydroxy-3-oxo-6beta,7beta:15beta,16beta-dimethyleneandrostan-17-yl)propionic acid ethyl ester→3-(5beta,17alpha-Dihydroxy-6beta,7beta:15beta,16beta-dimethylene-3-oxoandrostan-17-yl)-2-propynoic acid ethyl ester→3-(17alpha-Hydroxy-6beta,7beta:15beta,16beta-dimethylene-3-oxoandrost-4-en-17-yl)-2-propynoic acid ethyl ester→3-(17alpha-Hydroxy-6beta,7beta:15beta,16beta-dimethylene-3-oxoandrost-4-en-17-yl)propionic acid ethyl ester
(1aR,1bR,3S,5aR,5bS,7aS,8aS,9aS,9bS,9cR,9dR)-1b,3-Dihydroxy-5a,7a-dimethylperhydrocyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthren-8-one→(Ethoxycarbonyl)acetylene→3-[3beta,5beta,17beta-Trihydroxy-6beta,7beta:15beta,16beta-dimethyleneandrostan-17-yl]-2-propynoic acid ethyl ester→3-[5beta,17beta-Dihydroxy-6beta,7beta:15beta,16beta-dimethylene-3-oxoandrostan-17-yl]-2-propynoic acid ethyl ester→Ethyl 3-[(1aR,1bR,5aR,5bS,7aS,8S,8aS,9aS,9bS,9cR,9dR)-1b,8-dihydroxy-5a,7a-dimethyl-3-oxooctadecahydro-1H-cyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthren-8-yl]propanoate→Potassium 3-[(1aR,5aR,5bS,7aS,8S,8aS,9aS,9bS,9cR,9dR)-8-hydroxy-5a,7a-dimethyl-3-oxo-1a,3,4,5,5a,5b,6,7,7a,8,8a,9,9a,9b,9c,9d-hexadecahydro-1H-cyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthren-8-yl]propanoate→Sodium 3-[(1aR,5aR,5bS,7aS,8S,8aS,9aS,9bS,9cR,9dR)-8-hydroxy-5a,7a-dimethyl-3-oxo-1a,3,4,5,5a,5b,6,7,7a,8,8a,9,9a,9b,9c,9d-hexadecahydro-1H-cyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthren-8-yl]propanoate
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