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CAS 19882-75-8
(13S,14S)-13-ethyl-3-methoxy-6,7,8,12,13,14,15,16-octahydro-17H-cyclopenta[a]phenanthren-17-one
登记编号：ETON-020
应用背景（按来源药适应症）
避孕依托孕烯获得性免疫缺损综合征依托孕烯痛经依托孕烯血崩依托孕烯前列腺增生依托孕烯月经失调依托孕烯
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 依托孕烯Etonogestrel | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(8S,9S,10R,13S,14S)-13-ethyl-11-methylene-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-3H-cyclopenta[a]phenanthrene-3,17(2H)-dione→(13S,14S)-13-ethyl-3-methoxy-6,7,11,12,13,14,15,16-octahydro-17H-cyclopenta[a]phenanthren-17-one→(13S,14S)-13-ethyl-3-methoxy-6,7,8,12,13,14,15,16-octahydro-17H-cyclopenta[a]phenanthren-17-one→2,2-dimethylpropane-1,3-diol→(8S,13S,14S)-13-ethyl-3-methoxy-5',5'-dimethyl-6,7,8,12,13,14,15,16-octahydrospiro[cyclopenta[a]phenanthrene-17,2'-[1,3]dioxane]→(8S,9S,11R,13S,14S)-13-ethyl-3-methoxy-5',5'-dimethyl-6,7,8,9,11,12,13,14,15,16-decahydrospiro[cyclopenta[a]phenanthrene-17,2'-[1,3]dioxan]-11-ol→(8S,9S,13S,14S)-13-ethyl-3-methoxy-5',5'-dimethyl-6,8,9,12,13,14,15,16-octahydrospiro[cyclopenta[a]phenanthrene-17,2'-[1,3]dioxan]-11(7H)-one→(8S,9S,11S,13S,14S)-13-ethyl-3-methoxy-5',5'-dimethyl-11-((trimethylsilyl)methyl)-6,7,8,9,11,12,13,14,15,16-decahydrospiro[cyclopenta[a]phenanthrene-17,2'-[1,3]dioxan]-11-ol→(8S,9S,11S,13S,14S)-13-ethyl-3-methoxy-5',5'-dimethyl-11-((trimethylsilyl)methyl)-1,4,6,7,8,9,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-17,2'-[1,3]dioxan]-11-ol
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