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依托孕烯
Tier C · 观察 / 贸易Etonogestrel
欧加农
原研
1998
首批上市
-
到期年（公开口径）
无销量数据
峰值销售
化学药
类型
靶点：ERs、PR
商品名：Implanon/Nexplanon、Nexplanon、Implanon
适应症（已批准）：避孕
各地区研发/上市状态
美国
批准上市
2006-07-17
欧盟
批准上市
1998-08-25
中国
批准上市
2009-01-04
日本
-
合成路线与中间体5 routes
原研路线 × 1优化路线（非专利）× 4工艺路线 × 0
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
原研Route 1步骤 6 · 总收率 3.0 g
ETON-00153067-82-6ETON-002196716-43-5ETON-0031779-49-3ETON-0041240383-40-7ETON-00554024-17-8ETON-006123-75-1ETON-007—ETON-00874-86-2ETON-009—API · 依托孕烯
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| ETON-001 | 53067-82-6 | (8S,9S,10R,11R,13S,14S)-13-ethyl-11-hydroxy-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-3H-cyclopenta[a]phenanthrene-3,17(2H)-dione |
| ETON-002 | 196716-43-5 | (8'S,9'S,10'R,13'S,14'S)-13'-ethyl-1',2',6',7',8',9',10',12',13',14',15',16'-dodecahydro-11'H-dispiro[[1,3]dioxolane-2,3'-cyclopenta[a]phenanthrene-17',2''-[1,3]dioxolan]-11'-one |
| ETON-003 | 1779-49-3 | methyltriphenylphosphonium bromide |
| ETON-004 | 1240383-40-7 | (8'S,9'S,10'R,13'S,14'S)-13'-ethyl-11'-methylene-1',6',7',8',9',10',11',12',13',14',15',16'-dodecahydro-2'H-dispiro[[1,3]dioxolane-2,3'-cyclopenta[a]phenanthrene-17',2''-[1,3]dioxolane] |
| ETON-005 | 54024-17-8 | (8S,9S,10R,13S,14S)-13-ethyl-11-methylene-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-3H-cyclopenta[a]phenanthrene-3,17(2H)-dione |
| ETON-006 | 123-75-1 | pyrrolidine |
| ETON-007 | - | (8S,9S,10R,13S,14S)-13-ethyl-11-methylene-3-(pyrrolidin-1-yl)-1,2,7,8,9,10,11,12,13,14,15,16-dodecahydro-17H-cyclopenta[a]phenanthren-17-one |
| ETON-008 | 74-86-2在售 | ethyne |
| ETON-009 | - | (8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-11-methylene-3-(pyrrolidin-1-yl)-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol |
优化Route 2步骤 6 · 总收率 2.8 g
ETON-00153067-82-6ETON-00874-86-2ETON-0101161444-06-9ETON-0111161444-07-0ETON-0121253391-55-7ETON-01354024-18-9ETON-014116930-33-7API · 依托孕烯
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| ETON-001 | 53067-82-6 | (8S,9S,10R,11R,13S,14S)-13-ethyl-11-hydroxy-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-3H-cyclopenta[a]phenanthrene-3,17(2H)-dione |
| ETON-008 | 74-86-2在售 | ethyne |
| ETON-010 | 1161444-06-9 | (8S,9S,10R,11R,13S,14S)-13-ethyl-11-hydroxy-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dithiolan]-17(2H)-one |
| ETON-011 | 1161444-07-0 | (8'S,9'S,10'R,11'R,13'S,14'S)-13'-ethyl-1',6',7',8',9',10',11',12',13',14',15',16'-dodecahydro-2'H-dispiro[[1,3]dioxolane-2,17'-cyclopenta[a]phenanthrene-3',2''-[1,3]dithiolan]-11'-ol |
| ETON-012 | 1253391-55-7 | (8'S,9'S,10'R,13'S,14'S)-13'-ethyl-1',2',6',7',8',9',10',12',13',14',15',16'-dodecahydro-11'H-dispiro[[1,3]dioxolane-2,17'-cyclopenta[a]phenanthrene-3',2''-[1,3]dithiolan]-11'-one |
| ETON-013 | 54024-18-9 | (8S,9S,10R,13S,14S)-13-ethyl-11-methylene-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dithiolan]-17(2H)-one |
| ETON-014 | 116930-33-7 | (8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-11-methylene-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dithiolan]-17-ol |
优化Route 3步骤 6 · 总收率 2.9 g
ETON-018220332-82-1ETON-00554024-17-8ETON-006123-75-1ETON-007—ETON-00874-86-2ETON-015916815-51-5ETON-0161401227-50-6ETON-017—API · 依托孕烯
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| ETON-018 | 220332-82-1 | (8S,9S,10R,13S,14S,17S)-13-ethyl-17-hydroxy-11-methylene-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one |
| ETON-005 | 54024-17-8 | (8S,9S,10R,13S,14S)-13-ethyl-11-methylene-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-3H-cyclopenta[a]phenanthrene-3,17(2H)-dione |
| ETON-006 | 123-75-1 | pyrrolidine |
| ETON-007 | - | (8S,9S,10R,13S,14S)-13-ethyl-11-methylene-3-(pyrrolidin-1-yl)-1,2,7,8,9,10,11,12,13,14,15,16-dodecahydro-17H-cyclopenta[a]phenanthren-17-one |
| ETON-008 | 74-86-2在售 | ethyne |
| ETON-015 | 916815-51-5 | (13S,14S,17S)-13-ethyl-17-hydroxy-3-methoxy-6,7,12,13,14,15,16,17-octahydro-11H-cyclopenta[a]phenanthren-11-one |
| ETON-016 | 1401227-50-6 | (11S,13S,14S,17S)-13-ethyl-3-methoxy-11-((trimethylsilyl)methyl)-7,11,12,13,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthrene-11,17-diol |
| ETON-017 | - | (8S,9S,11S,13S,14S,17S)-13-ethyl-3-methoxy-11-((trimethylsilyl)methyl)-4,6,7,8,9,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-11,17-diol |
优化Route 4步骤 8 · 总收率 1.52 g
ETON-00554024-17-8ETON-01938393-52-1ETON-02019882-75-8ETON-021126-30-7ETON-0221433399-02-0ETON-0231433398-43-6ETON-0241433398-55-0ETON-0251433398-67-4ETON-0261433398-79-8API · 依托孕烯
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| ETON-005 | 54024-17-8 | (8S,9S,10R,13S,14S)-13-ethyl-11-methylene-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-3H-cyclopenta[a]phenanthrene-3,17(2H)-dione |
| ETON-019 | 38393-52-1 | (13S,14S)-13-ethyl-3-methoxy-6,7,11,12,13,14,15,16-octahydro-17H-cyclopenta[a]phenanthren-17-one |
| ETON-020 | 19882-75-8 | (13S,14S)-13-ethyl-3-methoxy-6,7,8,12,13,14,15,16-octahydro-17H-cyclopenta[a]phenanthren-17-one |
| ETON-021 | 126-30-7 | 2,2-dimethylpropane-1,3-diol |
| ETON-022 | 1433399-02-0 | (8S,13S,14S)-13-ethyl-3-methoxy-5',5'-dimethyl-6,7,8,12,13,14,15,16-octahydrospiro[cyclopenta[a]phenanthrene-17,2'-[1,3]dioxane] |
| ETON-023 | 1433398-43-6 | (8S,9S,11R,13S,14S)-13-ethyl-3-methoxy-5',5'-dimethyl-6,7,8,9,11,12,13,14,15,16-decahydrospiro[cyclopenta[a]phenanthrene-17,2'-[1,3]dioxan]-11-ol |
| ETON-024 | 1433398-55-0 | (8S,9S,13S,14S)-13-ethyl-3-methoxy-5',5'-dimethyl-6,8,9,12,13,14,15,16-octahydrospiro[cyclopenta[a]phenanthrene-17,2'-[1,3]dioxan]-11(7H)-one |
| ETON-025 | 1433398-67-4 | (8S,9S,11S,13S,14S)-13-ethyl-3-methoxy-5',5'-dimethyl-11-((trimethylsilyl)methyl)-6,7,8,9,11,12,13,14,15,16-decahydrospiro[cyclopenta[a]phenanthrene-17,2'-[1,3]dioxan]-11-ol |
| ETON-026 | 1433398-79-8 | (8S,9S,11S,13S,14S)-13-ethyl-3-methoxy-5',5'-dimethyl-11-((trimethylsilyl)methyl)-1,4,6,7,8,9,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-17,2'-[1,3]dioxan]-11-ol |
优化Route 5步骤 6 · 总收率 4.59 g
ETON-00153067-82-6ETON-00554024-17-8ETON-027100071-90-7ETON-028168131-50-8ETON-0291574323-07-1ETON-0301574323-08-2ETON-031149438-01-7API · 依托孕烯
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| ETON-001 | 53067-82-6 | (8S,9S,10R,11R,13S,14S)-13-ethyl-11-hydroxy-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-3H-cyclopenta[a]phenanthrene-3,17(2H)-dione |
| ETON-005 | 54024-17-8 | (8S,9S,10R,13S,14S)-13-ethyl-11-methylene-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-3H-cyclopenta[a]phenanthrene-3,17(2H)-dione |
| ETON-027 | 100071-90-7 | (8S,9S,10R,13S,14S)-13-ethyl-6,7,8,9,10,12,13,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,11,17(2H)-trione |
| ETON-028 | 168131-50-8 | (8S,9S,10R,13S,14S)-13-ethyl-1,2,4,7,8,9,10,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolane]-11,17-dione |
| ETON-029 | 1574323-07-1 | (8S,9S,10R,13S,14S)-13-ethyl-17-hydroxy-1,4,7,8,9,10,12,13,14,15,16,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-11(2H)-one |
| ETON-030 | 1574323-08-2 | (8S,9S,10R,13S,14S)-13-ethyl-11-methylene-1,2,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-17-ol |
| ETON-031 | 149438-01-7 | (8S,9S,10R,13S,14S)-13-ethyl-11-methylene-1,4,7,8,9,10,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-17(2H)-one |
常见问题（FAQ）
依托孕烯的适应症有哪些？
已批准的适应症包括：避孕。
依托孕烯的专利什么时候到期？
依托孕烯的专利到期年暂无公开口径，本页会在数据管道核实后更新。
依托孕烯有几条合成路线？
本站收录 5 条合成路线，最短路线 6 步、总收率 3.0 g。每条路线的中间体均带登记编号与 CAS 号。
依托孕烯的关键中间体在哪里可以采购？
依托孕烯的多条路线中间体已挂接 CAS 档案，其中 1 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。
如何获取依托孕烯中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-09-27