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CAS 218301-22-5
2-fluoro-5-formylbenzonitrile
登记编号：OLAP-004、ENTR-002
应用背景（按来源药适应症）
子宫内膜癌奥拉帕利去势抵抗性前列腺肿瘤奥拉帕利前列腺癌奥拉帕利腹膜癌奥拉帕利卵巢上皮癌奥拉帕利输卵管癌奥拉帕利实体瘤恩曲替尼非小细胞肺癌恩曲替尼
来源药（使用该中间体的合成路线）
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
3-hydroxyisobenzofuran-1(3H)-one→dimethyl phosphonate→dimethyl (3-oxo-1,3-dihydroisobenzofuran-1-yl)phosphonate→2-fluoro-5-formylbenzonitrile→(Z)-2-fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile→2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid→tert-butyl piperazine-1-carboxylate→tert-butyl 4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazine-1-carboxylate→4-(4-fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one→cyclopropanecarbonyl chloride
3-hydroxyisobenzofuran-1(3H)-one→2-fluoro-5-formylbenzonitrile→(Z)-2-fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile→2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid→cyclopropanecarbonyl chloride→2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzonitrile→cyclopropyl(piperazin-1-yl)methanone hydrochloride→piperazine
1-bromo-3,5-difluorobenzene→2-fluoro-5-formylbenzonitrile→5-((3,5-difluorophenyl)(hydroxy)methyl)-2-fluorobenzonitrile→5-(3,5-difluorobenzoyl)-2-fluorobenzonitrile→(3-amino-1H-indazol-5-yl)(3,5-difluorophenyl)methanone→N-(5-(3,5-difluorobenzoyl)-1H-indazol-3-yl)-2,2,2-trifluoroacetamide→N-(5-(3,5-difluorobenzoyl)-1-trityl-1H-indazol-3-yl)-2,2,2-trifluoroacetamide→(3-amino-1-trityl-1H-indazol-5-yl)(3,5-difluorophenyl)methanone→4-(4-methylpiperazin-1-yl)-2-nitrobenzoic acid hydrochloride→N-(5-(3,5-difluorobenzoyl)-1-trityl-1H-indazol-3-yl)-4-(4-methylpiperazin-1-yl)-2-nitrobenzamide→N-(5-(3,5-difluorobenzoyl)-1H-indazol-3-yl)-4-(4-methylpiperazin-1-yl)-2-nitrobenzamide→N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-methylpiperazin-1-yl)-2-nitrobenzamide→2-amino-N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-methylpiperazin-1-yl)benzamide→tetrahydro-4H-pyran-4-one
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 |
|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 2-Fluoro-5-formylbenzonitrile Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。