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CAS 1108745-16-9
N-(5-(3,5-difluorobenzoyl)-1-trityl-1H-indazol-3-yl)-2,2,2-trifluoroacetamide
登记编号：ENTR-007
应用背景（按来源药适应症）
实体瘤恩曲替尼非小细胞肺癌恩曲替尼
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 恩曲替尼Entrectinib | Tier C · 观察 / 贸易 | 2030 |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
1-bromo-3,5-difluorobenzene→2-fluoro-5-formylbenzonitrile→5-((3,5-difluorophenyl)(hydroxy)methyl)-2-fluorobenzonitrile→5-(3,5-difluorobenzoyl)-2-fluorobenzonitrile→(3-amino-1H-indazol-5-yl)(3,5-difluorophenyl)methanone→N-(5-(3,5-difluorobenzoyl)-1H-indazol-3-yl)-2,2,2-trifluoroacetamide→N-(5-(3,5-difluorobenzoyl)-1-trityl-1H-indazol-3-yl)-2,2,2-trifluoroacetamide→(3-amino-1-trityl-1H-indazol-5-yl)(3,5-difluorophenyl)methanone→4-(4-methylpiperazin-1-yl)-2-nitrobenzoic acid hydrochloride→N-(5-(3,5-difluorobenzoyl)-1-trityl-1H-indazol-3-yl)-4-(4-methylpiperazin-1-yl)-2-nitrobenzamide→N-(5-(3,5-difluorobenzoyl)-1H-indazol-3-yl)-4-(4-methylpiperazin-1-yl)-2-nitrobenzamide→N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-methylpiperazin-1-yl)-2-nitrobenzamide→2-amino-N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-methylpiperazin-1-yl)benzamide→tetrahydro-4H-pyran-4-one
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 |
|---|---|---|---|---|---|
| Unibest Taizhou GMP-like Site | 5-(3,5-difluorobenzyl)-1H-indazol-3-amine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | tert-butyl 4-(4-methylpiperazin-1-yl)-2-nitrobenzoate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | 5-(3,5-difluorobenzyl)-2-fluorobenzonitrile Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | tert-butyl 2-amino-4-(4-methylpiperazin-1-yl)benzoate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | 4-(4-methylpiperazin-1-yl)-2-[(tetrahydropyran-4-yl)(2,2,2-trifluoroacetyl)amino]benzoic acid trifluoroacetate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | 4-(4-methylpiperazin-1-yl)-2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)benzoicacid Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。