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CAS 2270865-23-9
1-[2-(Methanesulfonyl)pyrimidin-4-yl]-3-phenyl-1H-pyrazole-4-carbaldehyde
登记编号：(IX) 920279-3-a、(VII) 920279-4-a
应用背景（按来源药适应症）
非小细胞肺癌甲磺酸兰泽替尼肝功能衰退甲磺酸兰泽替尼
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 甲磺酸兰泽替尼Lazertinib Mesylate | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
2-Amino-5-fluoro-4-nitroanisole→1-Oxa-4-azacyclohexane→2-Methoxy-4-(morpholin-4-yl)-5-nitroaniline→2-Methoxy-4-morpholin-4-yl-5-nitrophenylformamide→5-Amino-2-methoxy-4-morpholin-4-ylphenylformamide→(Chloromethyl)acetyl chloride→3-Chloro-N-[5-formamido-4-methoxy-2-(morpholin-4-yl)phenyl]propanamide→N-[5-(Formylamino)-4-methoxy-2-morpholin-4-ylphenyl]acrylamide→1-[2-(Methanesulfonyl)pyrimidin-4-yl]-3-phenyl-1H-pyrazole-4-carbaldehyde→N-[5-[[4-(4-Formyl-3-phenyl-1H-pyrazol-1-yl)pyrimidin-2-yl]amino]-4-methoxy-2-(morpholin-4-yl)phenyl]prop-2-enamide→Dimethylamine hydrochloride→N-[5-[(4-[4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl]pyrimidin-2-yl)amino]-4-methoxy-2-(morpholin-4-yl)phenyl]prop-2-enamide→3-Phenyl-1H-pyrazole-4-carbaldehyde→4-Chloro-2-(methylsulfanyl)pyrimidine→1-[2-(Methylsulfanyl)pyrimidin-4-yl]-3-phenyl-1H-pyrazole-4-carbaldehyde
4-Chloro-2-(methylsulfanyl)pyrimidine→4-Chloro-2-(methanesulfonyl)pyrimidine→2-Methoxy-4-morpholin-4-yl-5-nitrophenylformamide→4-Chloro-N-[2-methoxy-4-(morpholin-4-yl)-5-nitrophenyl]pyrimidin-2-amine→3-Phenyl-1H-pyrazole-4-carbaldehyde→1-[2-[2-Methoxy-4-(morpholin-4-yl)-5-nitroanilino]pyrimidin-4-yl]-3-phenyl-1H-pyrazole-4-carbaldehyde→1-[2-(Methanesulfonyl)pyrimidin-4-yl]-3-phenyl-1H-pyrazole-4-carbaldehyde→Dimethylamine hydrochloride→4-[4-[(Dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl]-N-[2-methoxy-4-(morpholin-4-yl)-5-nitrophenyl]pyrimidin-2-amine→N1-[4-[4-[(Dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl]pyrimidin-2-yl]-6-methoxy-4-(morpholin-4-yl)benzene-1,3-diamine→(Chloromethyl)acetyl chloride→3-Bromopropanoyl chloride→3-Chloro-N-[5-[(4-[4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl]pyrimidin-2-yl)amino]-4-methoxy-2-(morpholin-4-yl)phenyl]propanamide→3-Bromo-N-[5-[(4-[4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl]pyrimidin-2-yl)amino]-4-methoxy-2-(morpholin-4-yl)phenyl]propanamide→N-[5-[(4-[4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl]pyrimidin-2-yl)amino]-4-methoxy-2-(morpholin-4-yl)phenyl]prop-2-enamide
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 3-phenyl-1H-pyrazole-4-carbaldehyde Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 4-Chloro-2-(methylsulfonyl)pyrimidine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 4-chloro-N-(2-methoxy-4-morpholino-5-nitrophenyl)pyrimidin-2-amine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | 1-(2-((2-methoxy-4-morpholino-5-nitrophenyl)amino)pyrimidin-4-yl)-3-phenyl-1H-pyrazole-4-carbaldehyde Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)-N-(2-methoxy-4-morpholino-5-nitrophenyl)pyrimidin-2-amine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | N1-(4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidin-2-yl)-6-methoxy-4-morpholinobenzene-1,3-diamine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。