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CAS 110-91-8
morpholine
登记编号：APIX-012、CARF-022、PEMIGA-027、SOTA-004、COBI-025、IXAB-012
应用背景（按来源药适应症）
肺栓塞阿哌沙班静脉血栓形成阿哌沙班Paget-Schroetter综合征阿哌沙班静脉血栓栓塞阿哌沙班血栓形成阿哌沙班栓塞阿哌沙班多发性骨髓瘤卡非佐米骨髓瘤佩米替尼淋巴瘤佩米替尼胆管癌佩米替尼胆管上皮癌佩米替尼胆道癌佩米替尼二型糖尿病索格列净慢性肾功能不全索格列净心脏衰竭索格列净HIV感染考比司他非小细胞肺癌考比司他获得性免疫缺损综合征考比司他乳腺癌伊沙匹隆转移性乳腺癌伊沙匹隆宫颈癌伊沙匹隆前列腺癌伊沙匹隆实体瘤伊沙匹隆中性粒细胞减少伊沙匹隆
来源药（使用该中间体的合成路线）
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
1-(4-iodophenyl)piperidin-2-one→ethyl (Z)-2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate→piperidin-2-one→3,3-dichloropiperidin-2-one→3-chloro-5,6-dihydropyridin-2(1H)-one→morpholine→3-morpholino-5,6-dihydropyridin-2(1H)-one→ethyl 1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate→1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid
4-iodoaniline→1-(4-iodophenyl)piperidin-2-one→3,3-dichloro-1-(4-iodophenyl)piperidin-2-one→1-(4-iodophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one→ethyl (Z)-2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate→piperidin-2-one→ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate→morpholine→5-bromopentanoic acid→5-bromo-N-(4-iodophenyl)pentanamide→3-chloro-1-(4-iodophenyl)-5,6-dihydropyridin-2(1H)-one→3-morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one
(tert-butoxycarbonyl)-L-leucine→(S)-2-((tert-butoxycarbonyl)amino)-4-phenylbutanoic acid→((S)-2-(2-morpholinoacetamido)-4-phenylbutanoyl)-L-leucyl-L-phenylalanine→(S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-aminium 2,2,2-trifluoroacetate→tert-butyl (S)-(1-(methoxy(methyl)amino)-4-methyl-1-oxopentan-2-yl)carbamate→tert-butyl (S)-(2,6-dimethyl-3-oxohept-1-en-4-yl)carbamate→tert-butyl ((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate→(S)-methyl 2-amino-3-phenylpropanoate→methyl (tert-butoxycarbonyl)-L-leucyl-L-phenylalaninate→(S)-1-(((S)-1-methoxy-1-oxo-3-phenylpropan-2-yl)amino)-4-methyl-1-oxopentan-2-aminium 2,2,2-trifluoroacetate→methyl ((S)-2-((tert-butoxycarbonyl)amino)-4-phenylbutanoyl)-L-leucyl-L-phenylalaninate→2-chloroacetyl chloride→methyl ((S)-2-(2-chloroacetamido)-4-phenylbutanoyl)-L-leucyl-L-phenylalaninate→morpholine→methyl ((S)-2-(2-morpholinoacetamido)-4-phenylbutanoyl)-L-leucyl-L-phenylalaninate→N,O-dimethylhydroxylamine hydrochloride→prop-1-en-2-ylmagnesium bromide
4-chloro-1H-pyrrolo[2,3-b]pyridine→4-chloro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine→4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde→4-(ethylamino)-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde→2,6-difluoro-3,5-dimethoxyaniline→5-(((2,6-difluoro-3,5-dimethoxyphenyl)amino)methyl)-N-ethyl-1H-pyrrolo[2,3-b]pyridin-4-amine→3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one→3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-7-(phenylsulfonyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one→3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-2-oxo-7-(phenylsulfonyl)-2,3,4,7-tetrahydro-1H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidine-8-carbaldehyde→morpholine→3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholinomethyl)-7-(phenylsulfonyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one→Pemigatinib
(3S,4R,5S)-tetrahydro-2H-pyran-2,3,4,5-tetraol→(3aS,5S,6R,6aS)-5-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-6-ol→(3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carboxylic acid→morpholine→((3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone→1-chloro-2-(4-ethoxybenzyl)-4-iodobenzene→(4-chloro-3-(4-ethoxybenzyl)phenyl)((3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanone→(2S,3S,4R,5R,6S)-6-(4-chloro-3-(4-ethoxybenzyl)phenyl)tetrahydro-2H-pyran-2,3,4,5-tetraol→(2R,3S,4R,5S,6S)-6-(4-chloro-3-(4-ethoxybenzyl)phenyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate→(2S,3S,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triyl triacetate→2-chloro-5-iodobenzoic acid→2-chloro-5-iodobenzoyl chloride→ethoxybenzene→(2-chloro-5-iodophenyl)(4-ethoxyphenyl)methanone
1-(2-isopropylthiazol-4-yl)-N-methylmethanamine→thiazol-5-ylmethyl ((2R,5R)-5-amino-1,6-diphenylhexan-2-yl)carbamate→(2R,5R)-1,6-diphenylhexane-2,5-diamine→4-nitrophenyl (thiazol-5-ylmethyl) carbonate→(S)-benzyl (1-hydroxy-3-phenylpropan-2-yl)carbamate→dibenzyl ((2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl)dicarbamate→di(1H-imidazol-1-yl)methanethione→dibenzyl ((1S,1'S)-((4R,5R)-2-thioxo-1,3-dioxolane-4,5-diyl)bis(2-phenylethane-1,1-diyl))dicarbamate→dibenzyl ((2S,5S,E)-1,6-diphenylhex-3-ene-2,5-diyl)dicarbamate→(S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanoic acid→(S)-3-aminodihydrofuran-2(3H)-one hydrobromide→(S)-1-((2-isopropylthiazol-4-yl)methyl)-1-methyl-3-(2-oxotetrahydrofuran-3-yl)urea→(S)-benzyl 4-hydroxy-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)butanoate→(S)-benzyl 2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-oxobutanoate→morpholine→(S)-benzyl 2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanoate
1-(2-isopropylthiazol-4-yl)-N-methylmethanamine→(2R,5R)-1,6-diphenylhexane-2,5-diamine→4-nitrophenyl (thiazol-5-ylmethyl) carbonate→(S)-3-aminodihydrofuran-2(3H)-one hydrobromide→(S)-1-((2-isopropylthiazol-4-yl)methyl)-1-methyl-3-(2-oxotetrahydrofuran-3-yl)urea→morpholine→(S)-2-benzylaziridine→dimethylsulfamoyl chloride→(S)-2-benzyl-N,N-dimethylaziridine-1-sulfonamide→COBI-030→(2S,5S,E)-1,6-diphenylhex-3-ene-2,5-diamine→(2R,5R)-1,6-diphenylhexane-2,5-diamine dihydrochloride→thiazol-5-ylmethyl ((2R,5R)-5-amino-1,6-diphenylhexan-2-yl)carbamate hydrochloride→potassium (S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanoate→(S)-2-amino-4-(methylthio)butanoic acid→(S)-ethyl 4-iodo-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)butanoate→(S)-ethyl 2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanoate oxalate
N-((1R,2R)-1-hydroxy-1-phenylpropan-2-yl)-N-methylpropionamide→5-bromopent-1-ene→(S)-N-((1R,2R)-1-hydroxy-1-phenylpropan-2-yl)-N,2-dimethylhept-6-enamide→(1S,2S)-1-(((1R,2R)-1-hydroxy-1-phenylpropan-2-yl)(methyl)amino)-2-methylhept-6-en-1-ol→(S)-2-methylhept-6-enal→3-((tert-butyldimethylsilyl)oxy)-4,4-dimethyl-5-oxoheptanoic acid→(3S,6R,7S,8S)-3-((tert-butyldimethylsilyl)oxy)-7-hydroxy-4,4,6,8-tetramethyl-5-oxotridec-12-enoic acid→(S,1E,5E)-2-methyl-1-(2-methylthiazol-4-yl)hepta-1,5-dien-3-amine→(3S,6R,7S,8S)-3-((tert-butyldimethylsilyl)oxy)-7-hydroxy-4,4,6,8-tetramethyl-N-((S,1E,5E)-2-methyl-1-(2-methylthiazol-4-yl)hepta-1,5-dien-3-yl)-5-oxotridec-12-enamide→(4S,7R,8S,9S,16S,Z)-4-((tert-butyldimethylsilyl)oxy)-8-hydroxy-5,5,7,9,13-pentamethyl-16-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)azacyclohexadec-13-ene-2,6-dione→(4S,7R,8S,9S,16S,Z)-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)azacyclohexadec-13-ene-2,6-dione→morpholine→isobutyraldehyde→4-(2-methylprop-1-en-1-yl)morpholine→(8R,9S,10R,13S,14S,17R)-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl pentanoate→2,2-dimethyl-3-oxopentanal→allylbis(4,6,6-trimethylbicyclo[3.1.1]hept-2-en-3-yl)borane→tert-butyldimethylsilyl trifluoromethanesulfonate→5-((tert-butyldimethylsilyl)oxy)-4,4-dimethyloct-7-en-3-one→3-((tert-butyldimethylsilyl)oxy)-4,4-dimethyl-5-oxoheptanal→(S,E)-2-aminopent-3-enoic acid→(S,E)-2-((tert-butoxycarbonyl)amino)pent-3-enoic acid→tert-butyl (S,E)-(1-(methoxy(methyl)amino)-1-oxopent-3-en-2-yl)carbamate→tert-butyl (S,E)-(2-oxohept-5-en-3-yl)carbamate→((2-methylthiazol-4-yl)methyl)diphenylphosphine oxide→tert-butyl ((S,1E,5E)-2-methyl-1-(2-methylthiazol-4-yl)hepta-1,5-dien-3-yl)carbamate→methoxybis(4,6,6-trimethylbicyclo[3.1.1]hept-2-en-3-yl)borane
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