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CAS 42518-98-9
5-chlorothiophene-2-carbonyl chloride
登记编号：RIVA-013
应用背景（按来源药适应症）
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来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 利伐沙班Rivaroxaban | Tier A · 立即攻坚 | 2026 |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
2-aminoethan-1-ol→2-chloroacetyl chloride→2-(2-chloroacetamido)ethyl 2-chloroacetate→2-chloro-N-(2-hydroxyethyl)acetamide→morpholin-3-one→1-fluoro-4-nitrobenzene→4-(4-nitrophenyl)morpholin-3-one→4-(4-aminophenyl)morpholin-3-one→(S)-2-(oxiran-2-ylmethyl)isoindoline-1,3-dione→(R)-2-(2-hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)isoindoline-1,3-dione→(S)-2-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione→(S)-4-(4-(5-(aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one oxalate→5-chlorothiophene-2-carbonyl chloride
4-(4-aminophenyl)morpholin-3-one→5-chlorothiophene-2-carbonyl chloride→5-chlorothiophene-2-carbaldehyde→5-chlorothiophene-2-carboxylic acid→(S)-3-aminopropane-1,2-diol hydrochloride→(S)-5-chloro-N-(2,3-dihydroxypropyl)thiophene-2-carboxamide→(S)-N-(3-bromo-2-hydroxypropyl)-5-chlorothiophene-2-carboxamide→(R)-5-chloro-N-(2-hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)thiophene-2-carboxamide
2-chloroacetyl chloride→4-(4-nitrophenyl)morpholin-3-one→4-(4-aminophenyl)morpholin-3-one→5-chlorothiophene-2-carbonyl chloride→2-(phenylamino)ethan-1-ol→4-phenylmorpholin-3-one→benzyl carbonochloridate→benzyl (4-(3-oxomorpholino)phenyl)carbamate→(R)-oxiran-2-ylmethyl butyrate→(R)-4-(4-(5-(hydroxymethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one→(R)-(2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl methanesulfonate→2-methylpropan-2-amine→(S)-4-(4-(5-((tert-butylamino)methyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one→(S)-N-(tert-butyl)-5-chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide
5-chlorothiophene-2-carbonyl chloride→benzyl (4-(3-oxomorpholino)phenyl)carbamate→(S)-2-(chloromethyl)oxirane→benzaldehyde→(S,E)-1-(benzylideneamino)-3-chloropropan-2-ol→(S)-1-amino-3-chloropropan-2-ol hydrochloride→(S)-5-chloro-N-(3-chloro-2-hydroxypropyl)thiophene-2-carboxamide→(S)-1-chloro-3-(5-chlorothiophene-2-carboxamido)propan-2-yl acetate
4-(4-aminophenyl)morpholin-3-one→5-chlorothiophene-2-carbonyl chloride→(R)-4-(4-(5-(hydroxymethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one→(S)-3-(benzyloxy)-2-hydroxypropyl 4-methylbenzenesulfonate→(S)-1-(benzyloxy)-3-(tosyloxy)propan-2-yl acetate→(R)-1-(benzyloxy)-3-((4-(3-oxomorpholino)phenyl)amino)propan-2-yl acetate→(R)-1-(benzyloxy)-3-((chlorocarbonyl)(4-(3-oxomorpholino)phenyl)amino)propan-2-yl acetate→(R)-4-(4-(5-((benzyloxy)methyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one→(R)-(2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl 4-methylbenzenesulfonate→(S)-4-(4-(5-((benzylamino)methyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one→(S)-N-benzyl-5-chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide
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同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 |
|---|---|---|---|---|---|
| Qualified Partner — East China API Works | 5-Chlorothiophene-2-carbonyl chloride Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
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